Lung transplant drug trial halted: new inhaled therapy shows promise but study ends early

NCT ID NCT04039347

Terminated Disease control Sponsor: Zambon SpA Source: ClinicalTrials.gov ↗

First seen Apr 09, 2026 · Last updated May 11, 2026 · Updated 4 times

Summary

This study tested an inhaled form of cyclosporine A (L-CsA) plus standard care in 164 people who had a lung transplant and developed bronchiolitis obliterans, a condition that scars the small airways. The goal was to see if the treatment could slow lung function decline over 24 to 48 weeks. The trial was terminated early, so final results are limited.

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Contacts and locations

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Locations

Banner - University Medical Center

Phoenix, Arizona, 85006, United States
Barnes-Jewish Hospital

St Louis, Missouri, 63110, United States
Baylor College of Medicine

Houston, Texas, 77030, United States
Baylor University Medical Center

Dallas, Texas, 75246, United States
CHU Hopital Nord

Marseille, France
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Columbia University Medical Center

New York, New York, 10032, United States
Complexo Hospitalario de A Coruna

A Coruña, Spain
Copenhagen University Hospital

Copenhagen, Denmark
David Geffen School of Medicine at UCLA

Los Angeles, California, 90095, United States
Duke University

Durham, North Carolina, 27710, United States
Hannover Medical School

Hanover, Germany
Hopital Marie Lannelongue

Le Plessis-Robinson, 92350, France
Hopitaux Universitaires de Strasbourg

Strasbourg, France
Hospital Marques de Valdecilla

Santander, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Spain
Hospital Universitario Puerta de Hierro - Unidad de Trasplante Pulmonar

Madrid, 28222, Spain
Houston Methodist Hospital

Houston, Texas, 77030, United States
Hôpital Erasme

Brussels, 1070, Belgium
Indiana University

Indianapolis, Indiana, 46202, United States
Johns Hopkins University Hospital

Baltimore, Maryland, 21287, United States
LMU Klinikum Groshadern

Munich, Germany
OSU Wexner Medical Center

Columbus, Ohio, 43210, United States
Rabin Medical Center

Petah Tikva, Israel
Royal Papworth Hospital NHS Foundation Trust

Cambridge, CB23 3RE, United Kingdom
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
UCSF

San Francisco, California, 94143, United States
UCSF Center for Advanced Lung Disease

Stanford, California, 94305, United States
UK Albert B. Chandler Hospital

Lexington, Kentucky, 40508, United States
Unidad de Trasplante Pulmonar del Hospital La Fe

Valencia, 46026, Spain
Universitair Ziekenhuis Leuven

Leuven, 3000, Belgium
University of Florida Dept of Pulmonary Medicine

Gainesville, Florida, 32610, United States
University of Manchester

Manchester, United Kingdom
University of Maryland

Baltimore, Maryland, 21201, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Waehringer Guertel

Vienna, Austria

Conditions

Explore the condition pages connected to this study.

BRONCHIOLITIS OBLITERANS BRONCHIOLITIS OBLITERANS SYNDROME OBLITERATIVE BRONCHIOLITIS