Can new scans catch lung transplant failure before It's too late?
NCT ID NCT06406777
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This study tests whether advanced imaging techniques, including oxygen-enhanced MRI and hyperpolarized xenon MRI, can detect chronic lung allograft dysfunction (CLAD) earlier than standard lung function tests. CLAD is a common complication after lung transplantation that can lead to organ failure. The study will compare these imaging methods with spirometry and CT scans in lung transplant recipients and healthy volunteers. The goal is to see if these scans can provide a more accurate and earlier diagnosis, which could help guide treatment and improve outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Diagnostic imaging tests: spirometry, contrast CT scan, oxygen-enhanced MRI, and hyperpolarized xenon (129Xe) MRI
- What this could lead to
- If successful, these imaging techniques could provide a more accurate and earlier diagnosis of chronic lung allograft dysfunction, potentially improving treatment timing and outcomes for lung transplant recipients.
- What could go wrong
- This is an early-stage study, and the imaging methods may not prove more effective than current standard tests. There are also risks associated with contrast agents and radiation exposure from CT scans.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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