New inhaled therapy aims to stop lung decline after transplant
NCT ID NCT05654922
First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 3 times
Summary
This Phase 3 trial tests an inhaled drug called ARINA-1 in 100 people who have had a double lung transplant and are showing early signs of lung function loss. The goal is to see if adding ARINA-1 to standard care can prevent further decline in lung function and improve quality of life over 48 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ARINA-1 (a nebulized mix of ascorbic acid and glutathione)
- What this could lead to
- If it works, this could offer a new way to slow or stop lung function decline in lung transplant patients, potentially reducing the need for stronger immune-suppressing drugs.
- What could go wrong
- This is a Phase 3 trial, but it's still relatively small (100 people) and open-label, which can bias results. The treatment may not work better than standard care, and side effects from the inhaled drug are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Advent Health
RECRUITINGOrlando, Florida, 32803, United States
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Baylor Scott and White Research Institute
RECRUITINGDallas, Texas, 75246, United States
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Baylor St. Luke's Medical Center
RECRUITINGHouston, Texas, 77030, United States
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
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Dignity Health - St. Joseph's Hospital and Medical Center
WITHDRAWNPhoenix, Arizona, 85013, United States
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Houston Methodist Hospital
RECRUITINGHouston, Texas, 77030, United States
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Inova Fairfax Hospital
RECRUITINGFalls Church, Virginia, 22042, United States
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Johns Hopkins Hospital
RECRUITINGBaltimore, Maryland, 21287, United States
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Loyola University Medical Center
RECRUITINGMaywood, Illinois, 60153, United States
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Mayo Clinic
NOT_YET_RECRUITINGRochester, Minnesota, 55905, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29452, United States
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Temple University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19122, United States
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The Ohio State University Wexner Medical Center
RECRUITINGColumbus, Ohio, 43221, United States
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University of California Los Angeles School of Medicine
RECRUITINGLos Angeles, California, 90095, United States
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University of California San Diego Health
RECRUITINGSan Diego, California, 92103, United States
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University of Iowa Hospital
RECRUITINGIowa City, Iowa, 52242, United States
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University of Minnesota Medical School
WITHDRAWNMinneapolis, Minnesota, 55455, United States
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University of South Florida
RECRUITINGTampa, Florida, 33606, United States
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University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 45390, United States
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Vanderbilt University Medical Center
NOT_YET_RECRUITINGNashville, Tennessee, 37232, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States