Asthma drug dupilumab targets lung mucus in new imaging study

NCT ID NCT04400318

Completed Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested dupilumab (Dupixent) in 109 adults with uncontrolled moderate-to-severe asthma. Researchers used lung scans and breathing tests to see if the drug reduces airway inflammation and mucus plugging. Participants received either dupilumab or a placebo for 24 weeks. The goal was to understand how dupilumab improves lung function and asthma control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Dupilumab (Dupixent)

What this could lead to

If successful, this could confirm dupilumab's ability to reduce lung inflammation and mucus buildup, improving breathing and asthma control.

What could go wrong

This is a completed phase 4 study with 109 participants, so results are already in. However, benefits may not apply to all asthma types, and side effects like injection reactions or infections are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

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Locations

Allianz Research Institute Site Number : 8400020

Westminster, California, 92683, United States
American Health Research Site Number : 8400005

Charlotte, North Carolina, 28277, United States
Investigational Site Number : 1000002

Sofia, 1680, Bulgaria
Investigational Site Number : 1000003

Sofia, 1233, Bulgaria
Investigational Site Number : 1000004

Montana, 3403, Bulgaria
Investigational Site Number : 1000005

Sofia, 1202, Bulgaria
Investigational Site Number : 1000006

Sofia, 1233, Bulgaria
Investigational Site Number : 1000007

Stara Zagora, 6001, Bulgaria
Investigational Site Number : 1000008

Rousse, 7002, Bulgaria
Investigational Site Number : 1000010

Sofia, 1431, Bulgaria
Investigational Site Number : 1000011

Sofia, 1407, Bulgaria
Investigational Site Number : 1000012

Plovdiv, 4002, Bulgaria
Investigational Site Number : 1000013

Dupnitsa, 2600, Bulgaria
Investigational Site Number : 1000015

Sofia, 1000, Bulgaria
Investigational Site Number : 1000018

Plovdiv, 4000, Bulgaria
Investigational Site Number : 1580001

Taipei, 110, Taiwan
Investigational Site Number : 1580002

Taichung, 40447, Taiwan
Investigational Site Number : 1580003

Tainan, 704, Taiwan
Investigational Site Number : 1580004

Kaohsiung City, 807, Taiwan
Investigational Site Number : 2080001

Hvidovre, 2650, Denmark
Investigational Site Number : 2080002

Copenhagen, 2100, Denmark
Investigational Site Number : 2080003

Copenhagen Nv, 2400, Denmark
Investigational Site Number : 2080006

Aarhus N, 8200, Denmark
Investigational Site Number : 2500001

Montpellier, France
Investigational Site Number : 3800001

Pisa, 56124, Italy
Investigational Site Number : 3800003

Cona, Ferrara, 44124, Italy
Investigational Site Number : 3800004

Rozzano, Milano, 20089, Italy
Investigational Site Number : 6200001

Porto, 4202-451, Portugal
Investigational Site Number : 6200003

Porto, 4100-180, Portugal
Investigational Site Number : 6200004

Coimbra, 3000-075, Portugal
Investigational Site Number : 6200005

Guimarães, 4810-061, Portugal
Investigational Site Number : 6200006

Lisbon, 1649-035, Portugal
Investigational Site Number : 6420001

Cluj-Napoca, 400371, Romania
Investigational Site Number : 6420003

Timișoara, 300134, Romania
Investigational Site Number : 6420005

Bragadiru, 769764, Romania
Investigational Site Number : 6420006

Cluj-Napoca, 400275, Romania
Investigational Site Number : 6420007

Oradea, 410155, Romania
Investigational Site Number : 6420008

Brasov, 500283, Romania
Investigational Site Number : 6820001

Riyadh, 11525, Saudi Arabia
Investigational Site Number : 6820002

Riyadh, 12372, Saudi Arabia
Investigational Site Number : 6820004

Jeddah, 21423, Saudi Arabia
Investigational Site Number : 6820006

Riyadh, 11426, Saudi Arabia
Investigational Site Number : 6820008

Dammam, 31952, Saudi Arabia
Investigational Site Number : 6820010

Riyadh, 12746, Saudi Arabia
Investigational Site Number : 7240001

Barcelona, Barcelona [Barcelona], 08035, Spain
Investigational Site Number : 7240002

Santiago de Compostela, Galicia [Galicia], 15706, Spain
Investigational Site Number : 7240003

Madrid, Madrid, Comunidad de, 28046, Spain
Investigational Site Number : 7240005

Madrid, Madrid, Comunidad de, 28041, Spain
Investigational Site Number : 7520001

Lund, 221 85, Sweden
Investigational Site Number : 8040001

Ivano-Frankivsk, 76018, Ukraine
Investigational Site Number : 8040002

Kharkiv, 61124, Ukraine
Investigational Site Number : 8040003

Chernivtsi, 58001, Ukraine
Investigational Site Number : 8040004

Kyiv, 01023, Ukraine
Investigational Site Number : 8040005

Odesa, 65025, Ukraine
Investigational Site Number : 8040007

Ternopil, 46000, Ukraine
Investigational Site Number : 8260001

Leicester, Leicestershire, LE3 9QP, United Kingdom
Investigational Site Number : 8260002

Bradford, BD9 6RJ, United Kingdom
Medical University of South Carolina - Pulmonary & Critical Care Clinical Research Program Site Number : 8400009

Charleston, South Carolina, 29425, United States
The Lung Research Center Site Number : 8400010

Chesterfield, Missouri, 63017, United States
University of Kansas School of Medicine Site Number : 8400008

Kansas City, Kansas, 66103, United States
University of Michigan Site Number : 8400002

Ann Arbor, Michigan, 48109, United States
Velocity Clinical Research, Medford Site Number : 8400014

Medford, Oregon, 97504, United States
VitaLink Research - Spartanburg Site Number : 8400011

Spartanburg, South Carolina, 29303, United States
VitaLink Research-Greenville Site Number : 8400013

Greenville, South Carolina, 29615, United States
~Spartanburg Medical Research Site Number : 8400004

Spartanburg, South Carolina, 29303, United States