New antibody drug aims to tame Hard-to-Control asthma

NCT ID NCT01867125

Completed Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study tests an experimental drug called lebrikizumab in people whose asthma remains uncontrolled despite daily use of inhaled steroids and a second controller medication. Participants receive either lebrikizumab or a placebo injection every 4 weeks for a year, while continuing their usual asthma treatments. The main goal is to see if lebrikizumab reduces the number of asthma attacks and improves lung function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental antibody drug called lebrikizumab
What this could lead to: If successful, lebrikizumab could offer a new treatment option for people with hard-to-control asthma, reducing the number of asthma attacks and improving daily breathing.
What could go wrong: This is a phase 3 trial, but results may not apply to all asthma patients. The drug may cause side effects or fail to show meaningful benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

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Locations

ADAC Research PA

Greenville, South Carolina, 29607, United States
ALL-MED Specjalistyczna Opieka Medyczna

Wroclaw, 50-445, Poland
ASTHMA, Inc

Seattle, Washington, 98105, United States
Advances in Medicine

Rancho Mirage, California, 92270, United States
Alabama Clinical Research Associates

Pell City, Alabama, 35128, United States
Albion Finch Medical Centre

Toronto, Ontario, M9V4B4, Canada
Alergologie Teplice, s.r.o.

Teplice, 415 01, Czechia
Alergopraktik s.r.o.

Jablonec nad Nisou, 466 01, Czechia
Alian s.r.o.

Bardejov, 085 01, Slovakia
Allergy & Asthma Associates

Las Vegas, Nevada, 89104, United States
Allergy & Asthma Center of NC

High Point, North Carolina, 27262, United States
Allergy & Asthma Diagnostic; Treatment Center

Tallahassee, Florida, 32308, United States
Allergy & Asthma Medical Group & Research Center, Pc

Long Beach, California, 90808, United States
Allergy & Asthma Research Grp

Eugene, Oregon, 97401-7721, United States
Allergy & Asthma Research of Nj, Inc

Mount Laurel, New Jersey, 08054, United States
Allergy Assoc Medical Group

San Diego, California, 92108, United States
Allergy Associates Research Center LLC - CRN

Portland, Oregon, 97202, United States
Allergy Medical Clinic

Los Angeles, California, 90025, United States
Allianz Medical and Research Center

Fountain Valley, California, 92708, United States
Anna Bogusz Gabinet Alergologiczny

Skarżysko-Kamienna, 26-110, Poland
Asan Medical Center

Seoul, 05505, South Korea
Asthma & Allergy Center

Toledo, Ohio, 43617, United States
Asthma & Allergy Center, P.C.

Papillion, Nebraska, 68046, United States
Asthma Allergy Phys of RI

Lincoln, Rhode Island, 02865, United States
Asthma Allergy Pulm Associates

Philadelphia, Pennsylvania, 19107, United States
Atatürk Gö?üs Hastal?klar? ve Gö?üs Cerrahisi E?itim ve Ara?t?rma Hastanesi

Ankara, 06290, Turkey (Türkiye)
Atlanta Allergy & Asthma Clini

Woodstock, Georgia, 30188, United States
Atlantic Research Center, LLC

Ocean City, New Jersey, 07712, United States
Azienda Ospedaliera Mater Domini Di Catanzaro

Catanzaro, Calabria, 88100, Italy
Barzilai Medical Center; Pulmonary Inst.

Ashkelon, 78306, Israel
Bellingham Asthma, Allergy & Immunology

Bellingham, Washington, 98225, United States
Bensch Research Associates

Stockton, California, 95207, United States
Box Hill Hospital; Eastern Clinical Research Unit

Box Hill, Victoria, 3128, Australia
C.C.C. Hospital Chest Diseases

Szeged, 6722, Hungary
C.I.C. Mauricie

Trois-Rivières, Quebec, G8T 7A1, Canada
CA Allergy & Asthma Med Grp

Los Angeles, California, 90025, United States
CHU Nantes - Hôpital Laennec; Service de Pneumologie

Nantes, 44093, France
Castle Hill Hospital; Respiratory Medicine

Cottingham, HU16 5JQ, United Kingdom
Central Clinical Hospital #1 of RZhD JCS

Moscow, 125367, Russia
Central Outpatient Hospital of Desnyansky District

Kyiv, 02232, Ukraine
Centro Médico Dra de Salvo

Buenos Aires, C1426ABP, Argentina
Centro Respiratorio Quilmes

Quilmes, B1878FNR, Argentina
Centro de Investigaciones Medicas Respiratorias

Santiago, 7500692, Chile
Centrum Alergologii Teresa Hofman

Poznan, 60-214, Poland
Centrum Medycyny Oddechowej Robert M. Mróz

Bialystok, 15-003, Poland
Choc Psf, Amc

Orange, California, 92868, United States
City Clinical Hospital #27

Kharkiv, 61002, Ukraine
City Outpatient Dept #94

Saint Petersburg, 193231, Russia
Clinical Hospital Center ''Bezanijska Kosa''; Department of Pulmology

Belgrade, 11080, Serbia
Clinical Research Inst. of Southern Oregon, Pc

Medford, Oregon, 97504, United States
Clinical Research Partners, LLC

Richmond, Virginia, 23220, United States
Cliniques Universitaires St-Luc

Brussels, 1200, Belgium
Colentina Clinical Hospital

Bucharest, 020125, Romania
Cor Clinical Research

Oklahoma City, Oklahoma, 73103, United States
Danylo Halytskyy National Medical University; Lviv

Lviv, 79010, Ukraine
Deepak Lakha MBCHB Private Practice

Johannesburg, 1820, South Africa
Desert Sun Clinical Research LLC

Tucson, Arizona, 85710, United States
Dr. Victor Babes Pneumology and Infectious Diseases Clinical Hospital

Timișoara, 300310, Romania
Dunedin Hospital

Dunedin, New Zealand
Emerald Coast Research Associates

Panama City, Florida, 32405, United States
Florida Pulmonary Research Institute, LLC

Winter Park, Florida, 32789, United States
Footscray Hospital

Footscray, Victoria, 3011, Australia
Fukuwa Clinic

Tokyo, 103-0027, Japan
Fundacion Faicep

Buenos Aires, C1122AAK, Argentina
Fundacion Neumologica Colombiana

Bogota DC, 11001, Colombia
Gatesville Medical Centre

Gatesville, 7746, South Africa
Grand View Hospital; Clinical Research Department

Sellersville, Pennsylvania, 18960, United States
Grazyna Pulka Specjalistyczny Osrodek ALL-MED

Krakow, 31-023, Poland
Heartland Clinical Research Inc.

Omaha, Nebraska, 68134, United States
Hopital Calmette; Pneumologie

Lille, 59037, France
Hosp Univ Fundacion Alcorcon

Madrid, 28922, Spain
Hospital Dr Angel Leaño universidad Autonoma de Guadalajara AC

Zapopan, 45200, Mexico
Hospital Germans Trias i Pujol

Barcelona, 08916, Spain
Hospital Universitario Araba

Vitoria-Gasteiz, Alava, 01004, Spain
Hospital Universitario Doctor Peset

Valencia, 46017, Spain
Hospital de la Santa Creu; i Sant Pau

Barcelona, 08025, Spain
Hôpital Arnaud de Villeneuve

Montpellier, 34295, France
IMMUNOe Research Centers

Centennial, Colorado, 80112, United States
Inspiration Research

Toronto, Ontario, M5T 3A9, Canada
Instituto Ave Pulmo

Mar del Plata, B7602DCK, Argentina
Instituto Jalisciense de Investigacion Clinica S.A. de C.V.

Santa Cecilia, Jalisco, 44700, Mexico
Interni A Pneumologicka Ambulance

Jindřichův Hradec, 377 38, Czechia
Investigaciones en Patologias Respiratorias

San Miguel de Tucumán, T4000IAR, Argentina
Iwate Medical University Hospital

Numakunai, 028-3695, Japan
Izmir Dr. Suat Seren Gogus Hastaliklari ve Cerrahisi Egitim ve Arastirma Hastanesi

Izmir, 35110, Turkey (Türkiye)
Japan Community Health Care Organization Hokkaido Hospital

Sapporo, 062-8618, Japan
Kaplan Medical Center

Rehovot, 7610001, Israel
Kenezy Korhaz Rendelointezet

Debrecen, 4031, Hungary
Kirikkale Universitesi Tip Fakultesi Hastanesi

Kirikkale, 71100, Turkey (Türkiye)
Klinika Chorób Wewnetrznych i Alergologii MSW

Warsaw, 02-507, Poland
Kochi Medical School Hospital

Kochi, 783-8505, Japan
Korea University Guro Hospital

Seoul, 08308, South Korea
Kyiv City Clinical Hospital #8

Kyiv, 04201, Ukraine
Kyushu Central Hospital

Fukuoka, 815-8588, Japan
LLC Medical Center Reavita Med SPb

Saint Petersburg, Sankt-Peterburg, 194354, Russia
Lady Davis Carmel Medical Center; Cardiovascular Medicine

Haifa, 34362, Israel
Manassas Clinical Research Center

Manassas, Virginia, 20110, United States
Medica Pro Familia Sp. z o.o. S.K.A.

Warsaw, 01-868, Poland
Meir Medical Center; Pulmonary Dept

Kfar Saba, 4428164, Israel
Melomed Hospital Gatesville

Cape Town, 7764, South Africa
MephaCentrum, a.s.

Ostrava - Poruba, 708 68, Czechia
Mersin University Medical Faculty

Mersin, 33169, Turkey (Türkiye)
Metroplex Pulmonology & Sleep Center

McKinney, Texas, 75069, United States
Midwest Clinical Research LLC

St Louis, Missouri, 63141, United States
Montana Medical Research LLC

Missoula, Montana, 59808, United States
Montefiore Medical Center

The Bronx, New York, 10461, United States
Municipal Institution of Kyiv Regional Council Kyiv Regional Clinical Hospital

Kyiv, 04107, Ukraine
NZ Respiratory & Sleep Institute

Auckland, 1051, New Zealand
Nagaoka Red Cross Hospital

Nagaoka-shi, 940-2085, Japan
National Hospital Organization Asahikawa Medical Center

Hokkaido, 070-8644, Japan
National Hospital Organization Mito Medical Center

Higashiibaraki-gun, 311-3193, Japan
National Hospital Organization Tokyo National Hospital

Kiyose-shi, 204-8585, Japan
Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o. sp.k.

Krakow, 31-637, Poland
Niigata City General Hospital

Niigata, 950-11977, Japan
Non-Commercial Enterprise City Clinical Hospital 1 of Zaporizhzhia City Council

Zaporizhzhia, 69104, Ukraine
North Bay Clinical Trials

Napa, California, 94558, United States
Northeast Medical Research Associates, Inc

North Dartmouth, Massachusetts, 02747, United States
Nouvel Hopital Civil; Pole de Pathologie Thoracique

Strasbourg, 67091, France
Novosibirsk Municipal Clinical Hospital For Emergency Medicine #2

Novosibirsk, 630008, Russia
O & O Alpan, LLC

Fairfax, Virginia, 22030, United States
Oji General Hospital

Hokkaido, 053-8506, Japan
Oki Clinic

Kodaira-shi, 187-0024, Japan
Osaka Metropolitan University Hospital

Osaka, 545-8586, Japan
P3 Research

Hastings, 4122, New Zealand
PMG Research of Wilmington

Wilmington, North Carolina, 28401, United States
Petz Aladar Megyei Oktato Korhaz

Győr, 9024, Hungary
Pharmaceutical Research & Consulting, Inc.

Dallas, Texas, 75231, United States
Pioneer Research Solutions

Houston, Texas, 077099, United States
Plucna ambulancia

Spišská Nová Ves, 052 01, Slovakia
Poradnia Pulmonologiczna dla Doroslych

Lódz, 90-153, Poland
Premier Clinical Research

Spokane, Washington, 99202, United States
Princeton Center For Clinical Research

Skillman, New Jersey, 08558, United States
Prof.Dr.Octavian Fodor Emergency Clinical Hospital

Cluj-Napoca, 400162, Romania
Public Institution City Clinical Hospital # 6 of Dnipropetrovsk Regional Board

Dnipro, 49000, Ukraine
Quality Assurance Research Ctr

San Antonio, Texas, 78205, United States
RMC Medical Research Ltd

Dunedin, New Zealand
Regional Phthisiology and Pulmonology Center

Ivano-Frankivsk, 76018, Ukraine
Russian Uni of People'S Friendship, Med. Faculty; City Clinical Hospital No 64, Internal Diseases

Moscow, 117292, Russia
Ryazan Regional Clinical Hosp

Ryazan, Ryazan Oblast, 390039, Russia
SHI Ctr Occupational Pathology

Saint Petersburg, Sankt-Peterburg, 195271, Russia
SIH Kemerovo Regional Clinical Hospital

Kemerovo, 650002, Russia
SPZOZ Proszowice

Proszowice, 32-100, Poland
Samsung Medical Center

Seoul, 06351, South Korea
Sano Toranomon Clinic

Tokyo, 105-0003, Japan
Schonffeldt y Guerrero Limitada

Santiago, 7500698, Chile
Sekino Hospital

Toshima City, 171-0014, Japan
Senzoku Kokyuuki and Allergy Clinic

Ōta-ku, 145-0063, Japan
Seoul National University Bundang Hospital

Seongnam-si, 463-707, South Korea
Shaare Zedek Medical Center

Jerusalem, 9103102, Israel
Showa University Hospital

Tokyo, 142-8666, Japan
Small Business Private Enterprise Medical Centre Pulse

Vinnytsia, 21001, Ukraine
Smolensk State Medical Academy

Smolensk, 4812, Russia
Spartanburg Medical Research

Spartanburg, South Carolina, 29303, United States
Specjalistyczne Centrum Medyczne NOWOMED

Krakow, 30-349, Poland
Spitalul Clinic de Boli Infectioase si Pneumoftiziologie Victor Babes Craiova

Craiova, 200515, Romania
St James University Hospital; Respiratory Department

Leeds, LS9 7TF, United Kingdom
St Peters Hospital

Chertsey, KT16 0PZ, United Kingdom
St-Petersburg Diagnostic Ctr#1; Pulmonology

Saint Petersburg, 194354, Russia
St. Francis Sleep; Allergy & Lung Institute

Clearwater, Florida, 33765, United States
St. Paul's Hospital, The Catholic University of Korea, College of Medicine

Seoul, 130-709, South Korea
St. Petersburg State Budget Medical Institution Pokrovskaya City Hospital

Saint Petersburg, 197022, Russia
St.-Petersburg SMU n. a. Academician I.P.Pavlov; Therapy Department

Saint Petersburg, 197022, Russia
Suncoast Research Group LLC

Miami, Florida, 33135, United States
TTS Research

Boerne, Texas, 78006, United States
Takahashi Clinic

Kokubunji-shi, 185-0014, Japan
Tehelná Clinic, Inc; IMUNO-ALERGO, s. r.o.

Bratislava, 831 03, Slovakia
Tekton Research Inc

Austin, Texas, 78745, United States
The Lung Institute of Western Australia; Sir Charles Gairdner Hospital

Nedlands, Western Australia, 6009, Australia
Tokyo Center Clinic; Internal Medicine

Tokyo, 103-0028, Japan
Tomsk Regional Clinical Hospital

Tomsk, 634063, Russia
Tono Chuo Clinic

Mizunami-shi, 509-6134, Japan
Tosei General Hospital; Respiratory and Allergy Medicine

Aichi, 489-8642, Japan
UZ Gent

Ghent, 9000, Belgium
Uludag University; Pulmonology and Allergy Department

Bursa, 16059, Turkey (Türkiye)
Uni of Cape Town Lung Inst.

Cape Town, 7925, South Africa
University of Fukui Hospital

Yoshida-gun, 910-1193, Japan
Università Degli Studi di Pisa - Ospedale di Cisanello Pisa

Pisa, Tuscany, 56124, Italy
Vawda Z.Fa Practice

Durban, 4091, South Africa
Waterbury Pulmonary Associates

Waterbury, Connecticut, 06708, United States
Yanovskyy Inst of Phth. & Pulm; Clinical-functional

Kyiv, 03680, Ukraine
Yokohama City Minato Red Cross Hospital

Kanagawa, 231-8682, Japan

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