New asthma drug aims to improve breathing without daily pills

NCT ID NCT02104674

Completed Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This phase 3 trial tests whether lebrikizumab, an injectable drug that blocks a protein involved in asthma inflammation, can improve lung function in adults with mild to moderate asthma. Participants receive either lebrikizumab injections, a placebo, or an open-label montelukast pill for 12 weeks. The study measures changes in how much air they can exhale in one second.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an injectable drug called lebrikizumab, which targets a protein involved in asthma inflammation
What this could lead to: If successful, this could provide a new treatment option for people with mild to moderate asthma that is not well controlled with current therapies.
What could go wrong: This is a phase 3 trial, but results may not show significant benefit over placebo, and lebrikizumab may cause side effects like injection site reactions or infections.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

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Locations

ALERGO-MED Specjalistyczna Przychodnia Lekarska Sp. z o. o

Tarnów, 33-100, Poland
Advanced Research Institute

Reno, Nevada, 89511, United States
Advances in Medicine

Rancho Mirage, California, 92270, United States
Aggarwal and Associates

Brampton, Ontario, L6T 0G1, Canada
Allergy & Asthma Center

Waco, Texas, 76712, United States
Allergy & Asthma Consultants

Redwood City, California, 94063, United States
Allergy & Asthma Immunology Associates

Scottsdale, Arizona, 85251, United States
Allergy Associates Research Center LLC - CRN

Portland, Oregon, 97202, United States
Allergy Asthma & Sinus Center

Greenfield, Wisconsin, 53228, United States
Allergy Asthma Research Assoc

Dallas, Texas, 75231, United States
Allergy, Asthma & Clinical Research Center

Oklahoma City, Oklahoma, 73120, United States
Anaheim Clinical Trials

Anaheim, California, 92801, United States
Asthma & Allergy Center of Chicago, S.C.

River Forest, Illinois, 60305, United States
Asthma & Allergy Center, P.C.

Papillion, Nebraska, 68046, United States
Atlantic Research Center, LLC

Ocean City, New Jersey, 07712, United States
Bandera Family Health Care

San Antonio, Texas, 78249, United States
CA Allergy & Asthma Med Grp; Medical Group, Inc.

Los Angeles, California, 90025, United States
City Hospital #40 of Resort Administrative District

Saint Petersburg, Sankt-Peterburg, 197706, Russia
Clinical Research Center of Alabama, LLC

Birmingham, Alabama, 35209, United States
Clinical Research Inst. of Southern Oregon, Pc

Medford, Oregon, 97504, United States
Clinical Research Partners, LLC

Richmond, Virginia, 23220, United States
Compartiment Pneumologie; Fundatia Dr. Victor Babes

Bucharest, 030303, Romania
Dr. Anil K. Gupta Medicine Professional Corporation

Toronto, Ontario, M9V 4B4, Canada
Faculdade de Medicina do ABC - FMABC; Oncologia e Hematologia

Santo André, São Paulo, 09060-650, Brazil
Family Allergy & Asthma

Louisville, Kentucky, 40223, United States
Florida Pulmonary Research Institute, LLC

Winter Park, Florida, 32789, United States
GRA?YNA JASIENIAK-PINIS ATOPIA Niepubliczny Zak?ad Opieki Zdrowotnej Poradnie Specjalistyczne

Krakow, 31-159, Poland
Grazyna Pulka Specjalistyczny Osrodek ALL-MED

Krakow, 31-023, Poland
I Engelbrecht Research

Lyttleton, 0157, South Africa
In-Quest Medical Research, LLC

Duluth, Georgia, 30096, United States
Integrated Research Group Inc

Riverside, California, 92506, United States
LLC Medical Center "Alliance-Biomedical - Russian Group"

Saint Petersburg, 190068, Russia
LLC Medical Center"REAVITA"

Saint Petersburg, 194295, Russia
MHAT "Sv. Ivan Rilski" ? Razgrad AD; Department of pnemology and phthisiatry

Razgrad, 7200, Bulgaria
MediTrial s.r.o.

Jind?ich?v Hradec, 377 01, Czechia
Medical Center Excelsior OOD

Sofia, 1000, Bulgaria
Medical Center Researchexpert OOD

Varna, 9000, Bulgaria
Medical Center Tara OOD

Veliko Tarnovo, 5000, Bulgaria
Metroplex Pulmonology & Sleep Center

McKinney, Texas, 75069, United States
Midwest Clinical Research LLC

St Louis, Missouri, 63141, United States
Mountainview Clinical Research

Greer, South Carolina, 29651, United States
Multiple-discipline City Hospital #2

Saint Petersburg, 194354, Russia
NZOZ ALL-MED Specjalistyczna Opieka Medyczna

Wroclaw, 53-201, Poland
NZOZ Alergo-Med. Specjalistyczna Przychodnia Lekarska; Poradnia Alergologiczna

Poznan, 60-823, Poland
National Jewish Health

Denver, Colorado, 80206, United States
Newtown Clinical Research

Johannesburg, 2113, South Africa
North Bay Clinical Trials

Napa, California, 94558, United States
O & O Alpan, LLC

Fairfax, Virginia, 22030, United States
Optimal Clinical Trials

Auckland, 1010, New Zealand
Ordinace pro tuberkulozu a respiracni nemoci

Strakonice, 38601, Czechia
Pesquisare Saúde Sociedade Simples

Santo André, São Paulo, 09080-000, Brazil
Pharmaceutical Research & Consulting, Inc.

Dallas, Texas, 75231, United States
Pneumo - KV; Ordinace pneumologie a diagnostiky plicních funkcí

Karlovy Vary ? Stará Role, 360 17, Czechia
Quality Assurance Research Center

San Antonio, Texas, 78207, United States
Regional Clinical Hospital

Saratov, 410053, Russia
Ryazan State Medical University Named after I.P.Pavlov

Ryazan, Ryazan Oblast, 390026, Russia
SBEI HPE "The First St.Petersburg State Medical University n.a. acad. I.P.Pavlova"of MoH of RF

Saint Petersburg, Sankt-Peterburg, 197022, Russia
SHATPD ? Gabrovo EOOD; Department of pneumology

Gabrovo, 5300, Bulgaria
SHATPPD Dr. Dimitar Gramatikov, Ruse Ltd.

Rousse, 7002, Bulgaria
Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
Sneeze, Wheeze, & Itch Associates

Normal, Illinois, 61761, United States
South Texas Allergy and Asthma Medical Professionals

San Antonio, Texas, 78251, United States
Southern California Institute For Respiratory

Los Angeles, California, 90048, United States
Southern Clinical Trials, Ltd

Beckenham, 8024, New Zealand
Soweto Clinical Trial Centre

Soweto, 1818, South Africa
Specjalistyczny Niepubliczny Zespol Opieki Zdrowotnej; Alergologia Plus Osrodek Diagnostyki.

Poznan, 60-693, Poland
Spitalul Clinic Municipal Dr. Gavril Curteanu Oradea; Sectia Pneumologie I

Oradea, 410176, Romania
Spitalul Clinic de Boli Infectioase si Pneumoftiziologie Dr. Victor Babes; Sectia Pneumologie II

Craiova, 200446, Romania
Spitalul Clinic de Pneumoftiziologie Iasi; Sectia Clinica I Pneumoftiziologie

Iași, 700115, Romania
St. Petersburg State Medical University n.a. I.P. Pavlov

Saint Petersburg, Sankt-Peterburg, 197089, Russia
Storms Clinical Research; Institute

Colorado Springs, Colorado, 80907, United States
Syzygy Clinical Research; ?Unit 3 to 7

Pretoria Gauteng Province, 0087, South Africa
TTS Research

Boerne, Texas, 78006, United States
Texas Institute of chest and Sleep Disorder

Houston, Texas, 77034, United States
The Clinical Research Ctr

St Louis, Missouri, 63141, United States
The Medicines Evaluation Unit

Manchester, M23 9QZ, United Kingdom
Tiervalei Trial Centre

Cape Town, 7530, South Africa
Ufsc - Nupaiva

Florianópolis, Santa Catarina, 88040-970, Brazil
University of Cape Town Lung Institute; Lung Clinical Research

Cape Town, 7700, South Africa
Uniwersytecki Szpital Kliniczny w Bialymstoku Klinika Alergologii i Chorob Wewnetrznych

Bialystok, 15-276, Poland
Ural State Medical University; Pulmonology

Yekaterinburg, 620109, Russia
Urban Health Plan, Inc.

The Bronx, New York, 10459, United States

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