Triple-drug inhaler aims to tame severe asthma in teens and adults

NCT ID NCT04609878

Completed Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests whether a three-in-one inhaler (budesonide, glycopyrronium, and formoterol) works better than two standard two-drug inhalers for people with asthma that is not well controlled. Adults and adolescents aged 12 to 80 with moderate-to-severe asthma will use the triple inhaler or one of the comparison inhalers for up to 24 weeks. The main goals are to measure improvements in lung function and reductions in severe asthma attacks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

budesonide, glycopyrronium, and formoterol fumarate metered dose inhaler

What this could lead to

If successful, this triple-combination inhaler could offer better asthma control and fewer severe attacks for people whose current treatment isn't enough.

What could go wrong

This is a large Phase 3 trial, but results may not apply to everyone. The added benefit over existing dual therapies may be modest, and side effects from the extra drug are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

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Saraland, Alabama, 36571, United States
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Phoenix, Arizona, 85018, United States
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Phoenix, Arizona, 85027, United States
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Sun City West, Arizona, 85375, United States
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Tucson, Arizona, 85715, United States
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Tucson, Arizona, 85745, United States
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Little Rock, Arkansas, 72209, United States
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Covina, California, 91723, United States
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Encinitas, California, 92024, United States
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Fresno, California, 93701, United States
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Laguna Hills, California, 92653, United States
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Long Beach, California, 90806, United States
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Los Angeles, California, 90017, United States
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Los Angeles, California, 90027, United States
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Mission Hills, California, 91345, United States
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Newport Beach, California, 92663, United States
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Northridge, California, 91324, United States
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San Diego, California, 92119, United States
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Stockton, California, 95207, United States
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Thousand Oaks, California, 91360, United States
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Upland, California, 91786, United States
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Westminster, California, 92683, United States
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Colorado Springs, Colorado, 80923, United States
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Lakewood, Colorado, 80228, United States
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Brandon, Florida, 33511, United States
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Miami, Florida, 33175, United States
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Tampa, Florida, 33607, United States
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Adairsville, Georgia, 30103, United States
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Atlanta, Georgia, 30344, United States
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Columbus, Georgia, 31904, United States
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Rincon, Georgia, 31326, United States
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Savannah, Georgia, 31406, United States
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Tyrone, Georgia, 30290, United States
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Chicago, Illinois, 60657, United States
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River Forest, Illinois, 60305, United States
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Brownsburg, Indiana, 46112, United States
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Indianapolis, Indiana, 46202, United States
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Louisville, Kentucky, 40217, United States
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Crowley, Louisiana, 70526, United States
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Lafayette, Louisiana, 70508, United States
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Cincinnati, Ohio, 45231, United States
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Edmond, Oklahoma, 73034, United States
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Oklahoma City, Oklahoma, 73120, United States
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Grants Pass, Oregon, 97527, United States
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DuBois, Pennsylvania, 15801, United States
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Pittsburgh, Pennsylvania, 15236, United States
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Pittsburgh, Pennsylvania, 15241, United States
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Scottdale, Pennsylvania, 15683, United States
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Smithfield, Pennsylvania, 15478, United States
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East Providence, Rhode Island, 02914, United States
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Anderson, South Carolina, 29621, United States
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Greenville, South Carolina, 29607, United States
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North Charleston, South Carolina, 29406, United States
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Franklin, Tennessee, 37067, United States
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Amarillo, Texas, 79106, United States
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Austin, Texas, 78759, United States
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Boerne, Texas, 78006, United States
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Cypress, Texas, 77429, United States
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Dallas, Texas, 75231, United States
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El Paso, Texas, 79912, United States
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Harlingen, Texas, 78550, United States
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Houston, Texas, 77021, United States
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Houston, Texas, 77030, United States
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Kerrville, Texas, 78028, United States
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Lampasas, Texas, 76550, United States
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Nederland, Texas, 77627, United States
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Pearland, Texas, 77584, United States
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Red Oak, Texas, 75154, United States
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San Antonio, Texas, 78215, United States
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San Antonio, Texas, 78229, United States
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San Antonio, Texas, 78258, United States
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Spring, Texas, 77386, United States
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Tomball, Texas, 77375, United States
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Ogden, Utah, 84404, United States
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West Valley City, Utah, 84120, United States
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Colchester, Vermont, 05446, United States
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Manassas, Virginia, 20110, United States
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Kingwood, West Virginia, 26537, United States
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Morgantown, West Virginia, 26505, United States
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Cudahy, Wisconsin, 53110, United States
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Buenos Aires, C1121ABE, Argentina
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CABA, 1056, Argentina
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CABA, C1425BEN, Argentina
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Ciudad de Buenos Aires, 1425, Argentina
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Ciudad de Buenos Aires, C1280AEB, Argentina
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Ciudad de Buenos Aires, C1414AIF, Argentina
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Córdoba, X5003DCE, Argentina
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Florida, B1602DQD, Argentina
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Mar del Plata, 7600, Argentina
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Mendoza, M5500CCG, Argentina
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Ranelagh, 1886, Argentina
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Rosario, 2000, Argentina
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San Fernando, B1646EBJ, Argentina
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Liège, 4000, Belgium
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Namur, 5101, Belgium
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Haskovo, 6305, Bulgaria
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Kozloduy, 3320, Bulgaria
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Lovech, 5500, Bulgaria
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Petrich, 2850, Bulgaria
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Rousse, 7000, Bulgaria
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Sevlievo, 5403, Bulgaria
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Sliven, 8800, Bulgaria
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Smolyan, 3700, Bulgaria
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Sofia, 1000, Bulgaria
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Stara Zagora, 6000, Bulgaria
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Varna, 9000, Bulgaria
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Veliko Tarnovo, 5000, Bulgaria
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Vidin, 3700, Bulgaria
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Vratsa, 3000, Bulgaria
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Sherwood Park, Alberta, T8H 2M7, Canada
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Kelowna, British Columbia, V1Y 4N7, Canada
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London, Ontario, N6A 1V2, Canada
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Chile, 7770484, Chile
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Curicó, 3341643, Chile
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Quillota, 2260000, Chile
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Santiago, 7500571, Chile
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Santiago, 7500698, Chile
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Santiago, 8207257, Chile
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Talca, 3481349, Chile
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Balassagyarmat, 2660, Hungary
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Budapest, 1204, Hungary
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Edelény, 3780, Hungary
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Encs, 3860, Hungary
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Gödöllő, 2100, Hungary
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Hajdúnánás, 4080, Hungary
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Komárom, 2900, Hungary
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Pécs, 7635, Hungary
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Szeged, 6720, Hungary
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Szeged, 6722, Hungary
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Szigetvár, 7900, Hungary
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Ahmedabad, 382415, India
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Aligarh, 202002, India
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Belagavi, 590010, India
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Coimbatore, 641028, India
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Dehradun, 248001, India
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Gurgaon, 122001, India
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Jaipur, 302039, India
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Mohali, 160062, India
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Nagpur, 440012, India
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New Delhi, 110029, India
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New Delhi, 110060, India
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New Delhi, 110075, India
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Thane, 401107, India
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Visakhapatnam, 530002, India
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Bari, 70124, Italy
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Casatenovo, 23880, Italy
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Cona, 44124, Italy
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Monserrato, 09042, Italy
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Naples, 80131, Italy
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Pisa, 56100, Italy
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Roma, 00133, Italy
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Roma, 00168, Italy
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Chino-shi, 391-0011, Japan
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Chūōku, 103-0022, Japan
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Chūōku, 103-0027, Japan
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Chūōku, 104-0031, Japan
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Fukui-shi, 910-8526, Japan
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Fukuoka, 811-1394, Japan
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Fukuoka, 819-8555, Japan
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Hamamatsu, 431-3192, Japan
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Higashiibaraki-gun, 311-3117, Japan
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Hiroshima-shi, Naka-ku, 730-0853, Japan
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Hitachi-Naka, 312-0057, Japan
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Kitakyushu, 802-0052, Japan
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Kyoto, 601-8213, Japan
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Nagoya, 457-0866, Japan
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Nankoku-shi, 783-8509, Japan
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Obihiro, 080-0017, Japan
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Omuta-shi, 837-0911, Japan
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Osaka, 530-0001, Japan
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Osaka, 531-0073, Japan
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Osaka, 551-0032, Japan
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Ōita, 870-8511, Japan
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Saga, 849-0917, Japan
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Sakaide-shi, 762-8550, Japan
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Sapporo, 064-0804, Japan
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Setagaya-ku, 157-0072, Japan
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Setagaya-ku, 158-0097, Japan
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Shibuya-ku, 150-0013, Japan
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Shimotsuga-gun, 321-0293, Japan
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Shinagawa-ku, 140-0001, Japan
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Shinagawa-ku, 140-8522, Japan
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Shinjuku-ku, 160-0004, Japan
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Shinjuku-ku, 160-8582, Japan
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Takarazuka-shi, 665-0827, Japan
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Tanabe-shi, 646-8558, Japan
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Toon-shi, 791-0281, Japan
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Toshima-ku, 170-0002, Japan
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Toshima-ku, 170-0003, Japan
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Toshima-ku, 171-0014, Japan
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Tsuchiura-shi, 300-8585, Japan
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Utsunomiya, 329-1193, Japan
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Yanagawa-shi, 832-0059, Japan
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Yokohama, 223-0059, Japan
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Yokohama, 231-8682, Japan
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Yokohama, 240-8555, Japan
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Auckland, 0626, New Zealand
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