Could a common antibiotic ease severe wheezing in young children?
NCT ID NCT04669288
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study investigates whether a 5-day course of oral azithromycin can reduce wheezing severity in preschool children (18 months to under 5 years) who come to the emergency department with a severe wheezing episode. Children are randomly assigned to receive either azithromycin or a placebo, and parents track symptoms daily using a validated diary. The goal is to see if the antibiotic improves recovery and reduces the need for further medical care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
azithromycin
What this could lead to
If effective, azithromycin could become a standard short-term treatment to ease severe wheezing episodes in young children, reducing symptoms and hospital stays.
What could go wrong
This is a Phase 3 trial, but results may vary by child. Azithromycin is an antibiotic, so overuse could contribute to resistance, and it may not work for all wheezing causes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Children's Healthcare of Atlanta, Emory University
Atlanta, Georgia, 30322, United States
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Children's Hospital of New York Medical Center
New York, New York, 10032, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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The Children's Hospital of Philadelphia (CHOP)
Philadelphia, Pennsylvania, 19104, United States
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The Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States