New drug aims to tame teen asthma that inhalers Can't control

NCT ID NCT01875003

Terminated Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests an experimental drug called lebrikizumab in teenagers aged 12 to 17 whose asthma is not well controlled even with daily inhalers and a second medication. Participants receive either lebrikizumab or a placebo as a shot every 4 weeks for a year, while continuing their usual asthma treatments. The goal is to see if lebrikizumab can reduce asthma attacks and improve lung function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

lebrikizumab

What this could lead to

If it works, this could offer a new add-on treatment option for teenagers whose asthma remains uncontrolled despite standard inhaler therapy.

What could go wrong

This is an early-phase trial, so the drug may not prove effective or could have side effects. Results may not apply to all asthma patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

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Locations

ALERGO-MED Specjalistyczna Przychodnia Lekarska Sp. z o. o

Tarnów, 33-100, Poland
Abel and Buchheim

Miami, Florida, 33165, United States
Alergologie Teplice, s.r.o.

Teplice, 415 01, Czechia
Allergy & Asthma Res Ctr PA

San Antonio, Texas, 78251, United States
Asthma & Allergy; Associates, P.C.

Colorado Springs, Colorado, 80907, United States
Asthma, Allergy & Sinus Center

Baltimore, Maryland, 21236, United States
Bensch Research Associates

Stockton, California, 95207, United States
Birmingham Heartlands Hospital

Birmingham, B9 5SS, United Kingdom
Bothe ke Bontle Health Services

Pretoria, 0101, South Africa
Bridgerland Clinical Research

North Logan, Utah, 84341, United States
CEMER Centro Médico de Enfermedades Respiratorias

Vicente López, B1602DQD, Argentina
CMPC/Clinica de Alergia Martti Antila

Sorocaba, São Paulo, 18040-425, Brazil
Centro Integral de Medicina Respiratoria (CIMER)

San Miguel de Tucumán, T4000CHE, Argentina
Centro de Investigacion Medico Biologico y Terapia Avanzada, S.C.

Guadalajara, Jalisco, 44130, Mexico
Centro de Investigación Ricardo Palma

Lima, LIMA 27, Peru
Centro de Referencia em Enfermidades Respiratorias e Alergia - CEAR

Salvador, Estado de Bahia, 41940-455, Brazil
Centrum Alergologii Teresa Hofman

Poznan, 60-214, Poland
Chaim Sheba Medical Center

Ramat Gan, 5265601, Israel
Clinica Internacional

Lima, Lima 1, Peru
Colorado Children's Hospital; The Breathing Institute

Aurora, Colorado, 80045, United States
Consultorio Especialidad Alergologia Pediatrica

Villahermosa, 86035, Mexico
Corporacio Sanitaria Parc Tauli; Servicio de Oncologia

Sabadell, Barcelona, 8208, Spain
Evangelisches Krankenhaus Hamm

Hamm, 59063, Germany
Faculdade de Medicina do ABC - FMABC

Santo André, São Paulo, 09060-650, Brazil
Fondazione IRCCS Policlinico San Matteo

Pavia, Lombardy, 27100, Italy
Georgia Pain Clinic

Marietta, Georgia, United States
Grupo Medico Camino

DF, Mexico CITY (federal District), Mexico
Heim Pál Gyermekkórház

Budapest, 1089, Hungary
Hofstetr Alois MUDr. s.r.o.

Jihlava, 586 01, Czechia
Hopital Charles Nicolle; cic

Rouen, 76031, France
Hospital CUF Porto; Servico de Imunoalergologia

Senhora Da Hora - Porto, 4460-188, Portugal
Hospital Infante D. Pedro; Servico de Imunoalergologia

Aveiro, 3814-501, Portugal
Hospital Particular do Algarve - Unidade de Faro

Faro, 8005-226, Portugal
Hospital Santa Clara

Bogotá, Colombia
Hospital Sao Lucas - PUCRS

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Universitario Germans Trias i Pujol; Servicio de Farmacia

Badalona, Barcelona, 08916, Spain
Hospital de Manises

Manises, Valencia, 46940, Spain
IMMUNOe Research Centers

Centennial, Colorado, 80112, United States
INAER

Buenos Aires, C1425BEN, Argentina
Imunoalergologia Dzurilla s.r.o.

Nitra, 949 01, Slovakia
Instituto Del Buen Aire

Santa Fe, S3000ASF, Argentina
Instituto Jalisciense de Investigacion Clinica S.A. de C.V.

Santa Cecilia, Jalisco, 44700, Mexico
Instituto Respirar

Mendoza, M5500GFA, Argentina
Instituto de Pesquisa Clínica e Medicina Avançada Ltda

São Paulo, São Paulo, 05437-010, Brazil
Investigaciones en Patologias Respiratorias

San Miguel de Tucumán, T4000IAR, Argentina
Kenezy Korhaz Rendelointezet

Debrecen, 4031, Hungary
Klinika Chorób Wewnetrznych i Alergologii MSW

Warsaw, 02-507, Poland
Malopolskie Centrum Alergologii

Krakow, 30-727, Poland
Municipal Institution "Kryvyi Rih City Clinical Hospital #8" of Dnipropetrovsk Regional Council

Kryvyi Rih, 50082, Ukraine
Municipal Institution Zaporizhzhya Regional Clinical Child Hospital

Zaporizhzhya, 69063, Ukraine
Municipal Medical Institution; Chernivtsi Regional Children's Hospital

Chernivtsi, 58023, Ukraine
National Cheng Kung Univ Hosp

Tainan, 00704, Taiwan
O & O Alpan, LLC

Fairfax, Virginia, 22030, United States
Papp és Társa Bt.

Szigetvár, 7900, Hungary
Pesquisare Saúde Sociedade Simples

Santo André, São Paulo, 09080-000, Brazil
Private Practice - Dr. Brian D. Lyttle

London, Ontario, N6A 5B8, Canada
Public Institution City Clinical Hospital # 6 of Dnipropetrovsk Regional Board

Dnipro, 49000, Ukraine
Rambam Health Care Campus

Haifa, 3109600, Israel
Rush University Medical Center

Chicago, Illinois, 60612, United States
SI National Institute of Phthisiology and Pulmonology n.a. F.G.Yanovskyi under NAMS of Ukraine

Kyiv, 03680, Ukraine
SI Research Centre of Radiation Medicine of AMSU

Kyiv, 3115, Ukraine
SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi

Lodz, 90-153, Poland
Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
Sarasota Clinical Research

Sarasota, Florida, 34239, United States
Schneider Children's Medical Center

Petah Tikva, 49100, Israel
Sebastian Peter

Durban, 4001, South Africa
Semmelweis Egyetem; Belgyogyaszati es Hematologiai Klinika

Budapest, 1088, Hungary
Shaare Zedek Medical Center

Jerusalem, 9103102, Israel
South Texas Allergy and Asthma Medical Professionals

San Antonio, Texas, 78251, United States
Southern California Research Center

Mission Viejo, California, 92691, United States
Soweto Clinical Trial Centre

Soweto, 1818, South Africa
State Institution of Pediatrics Obstetrics and Gynecology of NAMSU

Kiev, 04050, Ukraine
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

Szeged, 6720, Hungary
TTS Research

Boerne, Texas, 78006, United States
Uni of Cape Town Lung Inst.

Cape Town, 7925, South Africa
Unidad de Investigacion Clinica En Medicina (Udicem) S.C.

Monterrey, Nuevo León, 64718, Mexico
Universitaetsklinikum Frankfurt

Frankfurt, 60528, Germany
University of Leicester

Leicester, LE1 7RH, United Kingdom
Urban Health Plan, Inc.

The Bronx, New York, 10459, United States
WWCT Lakeview Hospital

Johannesburg, 1501, South Africa
Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi

Lodz, 93-513, Poland