New drug aims to free severe asthma patients from daily steroids

NCT ID NCT05398263

Terminated Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether tezepelumab, an injectable biologic, can help adults with severe asthma reduce their daily dose of oral corticosteroids while still keeping their asthma under control. Participants receive either tezepelumab or a placebo for 28 weeks, and doctors measure how much their steroid dose can be lowered. The goal is to find a safer, long-term treatment option for people who currently depend on steroids to manage their asthma.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tezepelumab
What this could lead to: If it works, this could help people with severe asthma reduce or stop taking oral steroids, lowering the risk of serious side effects while maintaining asthma control.
What could go wrong: This is a relatively small Phase 3 trial, and results may not apply to all asthma patients. Tezepelumab may not reduce steroid use enough, or could cause unexpected side effects.

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Conditions

The condition(s) this trial relates to.

asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

Locations

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Newport Beach, California, 92663, United States
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Denver, Colorado, 80206, United States
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Newark, Delaware, 19713, United States
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Hialeah, Florida, 33016, United States
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Miami Lakes, Florida, 33014, United States
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Lincoln, Nebraska, 68510, United States
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The Bronx, New York, 10459, United States
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El Paso, Texas, 79902, United States
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Kingwood, Texas, 77339, United States
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Botucatu, 18618-686, Brazil
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Curitiba, 80730-150, Brazil
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Porto Alegre, 90035074, Brazil
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Porto Alegre, 91350-200, Brazil
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Salvador, 40060-330, Brazil
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São Bernardo do Campo, 09715090, Brazil
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São Paulo, 01223-001, Brazil
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Sorocaba, 18040-425, Brazil
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Ajax, Ontario, L1S 2J5, Canada
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Québec, Quebec, G1V4G5, Canada
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Chile, 7770484, Chile
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Curicó, 3341643, Chile
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Santiago, 7500010, Chile
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Santiago, 7500588, Chile
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Santiago, 7500691, Chile
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Santiago, 7500698, Chile
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Santiago, 7750495, Chile
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Santiago, 8241479, Chile
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Brno, 625 00, Czechia
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Hradec Králové, 500 05, Czechia
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Jindřichův Hradec, 377 01, Czechia
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Miroslav, 671 72, Czechia
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Olomouc, 779 00, Czechia
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Ostrava, 700 30, Czechia
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Ajmer, 305001, India
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Kanpur, 208002, India
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Vadodara, 390022, India
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Guadalajara, 44100, Mexico
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Guadalajara, 44130, Mexico
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Guadalajara, 44200, Mexico
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Mexico City, 0 3100, Mexico
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Monterrey, 64460, Mexico
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San Luis Potosí City, 78250, Mexico
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Veracruz, 91910, Mexico
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Lima, 15046, Peru
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Bialystok, 15-704, Poland
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Bychawa, 23100, Poland
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Bydgoszcz, 85-231, Poland
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Chęciny, 26-060, Poland
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Grudziądz, 86-300, Poland
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Ostrowiec Świętokrzyski, 27-400, Poland
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Poznan, 61-578, Poland
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Rzeszów, 35-205, Poland
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Sosnowiec, 41-208, Poland
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Seoul, 05505, South Korea
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Seoul, 07061, South Korea
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Seoul, 143-729, South Korea
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Suwon, 16499, South Korea
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Bang Kra So, 11000, Thailand
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Bangkok, 10330, Thailand
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Hat Yai, 90110, Thailand
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Ankara, 06620, Turkey (Türkiye)
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Bursa, 16059, Turkey (Türkiye)
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Istanbul, 34899, Turkey (Türkiye)
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Izmir, 35040, Turkey (Türkiye)

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