Can a shot stop asthma before it starts? new trial tests omalizumab in toddlers

NCT ID NCT02570984

Ongoing Prevention Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving omalizumab (Xolair) to 2-3 year olds at high risk for asthma for two years can prevent the disease from developing. 200 children are enrolled in a double-blind, placebo-controlled trial. After treatment, they are monitored for another two years to see if they have fewer asthma symptoms and allergies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: omalizumab (Xolair)
What this could lead to: If successful, this could point toward a way to prevent asthma from developing in high-risk children.
What could go wrong: This is a Phase 2 trial with 200 kids, so results are preliminary. The benefit may not be large or lasting, and omalizumab injections can cause allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Childrens Hospital Colorado

Aurora, Colorado, 80045, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Connecticut Children's Hospital

Hartford, Connecticut, 06106, United States
Emory University

Atlanta, Georgia, 30322, United States
Indiana University/Riley Children's Hospital

Indianapolis, Indiana, 46202, United States
Phoenix Children's Hospital

Phoenix, Arizona, 85016, United States
Rady Children's Hospital - San Diego

San Diego, California, 92123, United States
Texas Children's Hospital/Baylor College of Medicine

Houston, Texas, 77030, United States
University of Wisconsin

Madison, Wisconsin, 53792, United States
Washington University

St Louis, Missouri, 63110, United States

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