New drug shows promise in reversing lung damage from severe asthma

NCT ID NCT03953300

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This study tests whether benralizumab can improve lung structure and function in people with severe eosinophilic asthma who still have symptoms despite standard treatments. About 75 adults aged 18-70 will receive either the drug or a placebo for 48 weeks, followed by a 4-week check-up. The goal is to see if the drug reduces airway inflammation and prevents long-term lung damage.

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Conditions

The condition(s) this trial relates to.

asthma lung disorder pulmonary eosinophilia T2-high asthma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Research Site

    Birmingham, Alabama, 35209, United States

  • Research Site

    Los Angeles, California, 90033, United States

  • Research Site

    Jacksonville, Florida, 32204, United States

  • Research Site

    Miami, Florida, 33166, United States

  • Research Site

    Snellville, Georgia, 30078, United States

  • Research Site

    Indianapolis, Indiana, 46268, United States

  • Research Site

    Iowa City, Iowa, 52242, United States

  • Research Site

    Kansas City, Kansas, 66160, United States

  • Research Site

    Ann Arbor, Michigan, 48109, United States

  • Research Site

    Bloomfield Hills, Michigan, 48301, United States

  • Research Site

    Rochester, Minnesota, 55905, United States

  • Research Site

    St Louis, Missouri, 63156, United States

  • Research Site

    Maspeth, New York, 11378, United States

  • Research Site

    New Bern, North Carolina, 28562, United States

  • Research Site

    Winston-Salem, North Carolina, 27104, United States

  • Research Site

    Pittsburgh, Pennsylvania, 15213, United States

  • Research Site

    Galveston, Texas, 77555, United States

  • Research Site

    Lewisville, Texas, 75067, United States

  • Research Site

    Mansfield, Texas, 76063, United States

  • Research Site

    Calgary, Alberta, T2N 4Z6, Canada

  • Research Site

    Aalborg, 9000, Denmark

  • Research Site

    Aarhus N, 8200, Denmark

  • Research Site

    Copenhagen, 2400, Denmark

  • Research Site

    Hvidovre, 2650, Denmark

  • Research Site

    Næstved, 4700, Denmark

  • Research Site

    Odense C, 5000, Denmark

  • Research Site

    Vejle, 7100, Denmark

  • Research Site

    Gothenburg, 413 45, Sweden

  • Research Site

    Lund, 22185, Sweden

  • Research Site

    Cambridge, CB2 2QQ, United Kingdom

  • Research Site

    Headington, OX3 9DU, United Kingdom

  • Research Site

    Leicester, LE3 9QP, United Kingdom

  • Research Site

    Liverpool, L7 8XP, United Kingdom

  • Research Site

    London, W1G 8HU, United Kingdom

  • Research Site

    Wythenshawe, M23 9LT, United Kingdom