Can a shot stop asthma attacks in city kids?
NCT ID NCT05347771
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding dupilumab (Dupixent) to standard asthma care can prevent asthma attacks in 240 urban children and teens aged 6–17 with severe, allergy-driven asthma. Participants receive either dupilumab or a placebo for 12 months. The main goal is to see if the drug reduces the number of asthma attacks that require steroids.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dupilumab (Dupixent)
What this could lead to
If it works, this could provide a new way to prevent severe asthma attacks in children and teens living in urban areas.
What could go wrong
This is a Phase 2 trial, so it's still early. The drug may not reduce attacks significantly, and side effects like injection reactions or infections are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago: Division of Allergy and Immunology
Chicago, Illinois, 60611, United States
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Boston Children's Hospital: Department of Immunology
Boston, Massachusetts, 02215, United States
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Children's Hospital Colorado: Allergy Program
Aurora, Colorado, 80045, United States
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Children's National Medical Center: Children's Research Institute
Washington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center: Asthma Center
Cincinnati, Ohio, 45229, United States
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Columbia University Medical Center: Division of Pediatric Pulmonology
New York, New York, 10032, United States
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Icahn School of Medicine at Mount Sinai: Division of Clinical Immunology, Immunology Institute
New York, New York, 10029, United States
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Washington University at St. Louis
St Louis, Missouri, 63110, United States