Can a shot stop asthma attacks in city kids?

NCT ID NCT05347771

Ongoing Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding dupilumab (Dupixent) to standard asthma care can prevent asthma attacks in 240 urban children and teens aged 6–17 with severe, allergy-driven asthma. Participants receive either dupilumab or a placebo for 12 months. The main goal is to see if the drug reduces the number of asthma attacks that require steroids.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dupilumab (Dupixent)
What this could lead to: If it works, this could provide a new way to prevent severe asthma attacks in children and teens living in urban areas.
What could go wrong: This is a Phase 2 trial, so it's still early. The drug may not reduce attacks significantly, and side effects like injection reactions or infections are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

asthma acute asthma prevention target status asthmaticus prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASTHMA

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago: Division of Allergy and Immunology

Chicago, Illinois, 60611, United States
Boston Children's Hospital: Department of Immunology

Boston, Massachusetts, 02215, United States
Children's Hospital Colorado: Allergy Program

Aurora, Colorado, 80045, United States
Children's National Medical Center: Children's Research Institute

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center: Asthma Center

Cincinnati, Ohio, 45229, United States
Columbia University Medical Center: Division of Pediatric Pulmonology

New York, New York, 10032, United States
Icahn School of Medicine at Mount Sinai: Division of Clinical Immunology, Immunology Institute

New York, New York, 10029, United States
Washington University at St. Louis

St Louis, Missouri, 63110, United States

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