Mcmaster University

This study tests whether a short-term program combining health coaching and medication can help people with type 2 diabetes achieve remission without surgery. It involves 118 adults diagnosed within the last 5 years, recruited from a primary care clinic in Hamilton, Ontario. The …

This study looks at how prostate cancer treatments, especially hormone therapy, affect heart health. It includes two parts: one that follows men over time to track heart problems, and another that tests whether a program of healthy eating, exercise, smoking cessation, and medicat…

This study was designed to see if taking metformin or salsalate on the morning of surgery could help control blood sugar and reduce complications in people with type 2 diabetes. It planned to enroll patients having elective surgery who regularly take metformin. However, the trial…

This study compares two ways of giving faricimab, a drug injected into the eye, to treat diabetic macular edema (DME). One group gets injections on a fixed monthly schedule, while the other uses a 'treat and extend' approach where the time between injections is gradually lengthen…

This study looks at a program called Back to Living Well, which combines exercise and self-management education to help people with ongoing low back pain. The goal is to reduce disability and prevent future flare-ups. About 90 adults with persistent low back pain will take part i…

This study compares two common surgeries for people who have repeated shoulder dislocations. One surgery repairs the torn ligament and may add a tendon fill (Bankart + Remplissage), while the other moves a piece of bone to block dislocation (Latarjet). The goal is to see which ap…

This study tests a new ultrasound technique called SonoPODography (SPG) to diagnose superficial endometriosis, the most common form of the disease. Currently, diagnosis requires invasive surgery. The procedure involves injecting saline into the pelvis to create a clearer view of …

This study tests a 12-week virtual program called Stepping-Up, designed to prevent early mobility decline in adults aged 55-75 who are starting to have trouble with walking. Participants are randomly assigned to Stepping-Up, a telephone-based walking coaching program, or a chair-…

This study was designed to find the best dose of intravenous lidocaine for controlling pain after bariatric bowel surgery. Lidocaine is a local anesthetic that may reduce the need for opioids, which can cause nausea and other side effects. The trial planned to compare two doses i…

This study tests whether switching to a Mediterranean diet can reduce pelvic pain in people with endometriosis. Twenty-four participants will either follow the diet for 12 weeks or stick with their usual eating habits. Researchers will measure pain, quality of life, and gut healt…

This study was designed to compare two types of nerve-blocking procedures for people with long-term knee pain from osteoarthritis. The goal was to see if targeting six nerves works better than the usual three nerves for reducing pain and improving daily function. The trial was wi…

This study tests whether a 10-week online group talking therapy (CBT) can help mothers and birthing parents with postpartum depression or anxiety. About 48 participants in Ontario will be randomly assigned to receive the therapy plus usual care, or usual care alone. The goal is t…

This study tests whether a 9-week online group therapy program (cognitive behavioural therapy) can help fathers and non-birthing parents who feel depressed during their partner's pregnancy or within the first 18 months after birth. About 48 participants in Ontario will be randoml…

This study tests whether a 9-week online group talk therapy program, co-led by a public health nurse and a mother who has recovered from postpartum depression, can reduce depression symptoms in new mothers. 170 mothers in Ontario with an infant under 12 months and signs of depres…

This study tests a program called SPA-LTC in long-term care homes to improve care for frail elderly residents near the end of life. The program includes training staff, using tools to start end-of-life conversations, and holding family meetings. Researchers will see if it reduces…

This study was designed to see if doctors could use an ultrasound machine to guide a diagnostic nerve block for low back pain. The procedure involves injecting numbing medicine near the small joints in the spine. However, the study was withdrawn before enrolling any participants,…

This study was designed to see if different types of anesthesia could help a surgically created blood vessel connection (called a fistula) work better for dialysis patients. The plan was to compare three methods: a nerve block in the armpit, a nerve block in the neck, and local a…

This study aimed to test different regional anesthesia techniques to help people recover faster and go home sooner after total knee replacement. It planned to compare a standard pain injection with an added nerve block or continuous nerve block infusion. However, the study was wi…

This study aimed to see if an online lesson could improve people's knowledge and healthy habits for preventing dementia. It planned to enroll Canadians aged 16 and older without dementia, giving some the prevention lesson and others a different topic. However, the study was withd…

This study follows 201 healthy teens aged 12-14 over two years to see if playing only one sport year-round leads to hip impingement (FAI), a condition where hip bones rub together. Participants get MRI scans and fill out questionnaires. The goal is to understand if early sport fo…