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Gentle lung breathing during bypass may prevent Post-Surgery collapse

NCT ID NCT02070445

Knowledge-focused Sponsor: McMaster University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This pilot study tests whether keeping the lungs gently ventilated during cardiopulmonary bypass (heart-lung machine) reduces lung collapse after heart surgery. Adults having elective coronary artery bypass surgery will be randomly assigned to receive ventilation or not during bypass. Lung ultrasound scans will measure collapse at several time points before and after surgery. The study also looks at infection rates, time on the breathing tube, hospital stay length, and blood oxygen levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mechanical ventilation during cardiopulmonary bypass
What this could lead to
If keeping the lungs ventilated during bypass reduces lung collapse, it could lead to faster recovery and fewer lung complications after heart surgery.
What could go wrong
This is a small pilot study focused on feasibility, not proof of benefit. The approach may not show a meaningful difference or may not be practical in busy surgical settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Expected to start

Jun 2019

An estimate. Start dates often move.

Expected to finish

Dec 2020

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Same Day Surgery Clinic

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult elective coronary artery bypass surgery requiring CPB Exclusion Criteria: * Cardiac surgery without CPB * Complex cardiac surgery (valve repairs, combined bypass and valve repairs etc.) * Emergency cardiac surgery * Fibrotic lung disease * Previous lung volume reduction surgery (CXR will be assessed pre-operatively) * Massive blood product transfusion intra- and/or post-operatively will exclude patient * Patients enrolled in other studies eg. SIRS study (steroid use)

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Conditions

The condition(s) this trial relates to.

coronary artery disorder middle lobe syndrome Pulmonary Atelectasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulmonary atelectasis

Contacts and locations

Locations

  • Hamilton General Hospital

    Hamilton, Ontario, L8L 2X2, Canada

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