Mcmaster University

This study tests a new COVID-19 vaccine that you breathe in as a mist, instead of getting a shot. It aims to see if it is safe and creates a strong immune response in the lungs and blood. About 350 healthy adults who have already had three mRNA COVID vaccines will receive either …

This early-stage trial tests whether an intravenous enzyme called DNase I is safe and feasible for ICU patients with sepsis. Sepsis is a life-threatening response to infection that can damage organs. The study will enroll 36 adults and monitor how many complete the treatment and …

This study looks at whether adding the drug semaglutide (Wegovy®) to a behavioral lifestyle program helps teenagers with obesity lose weight and adapt their metabolism. About 74 teens aged 12-17 will be split into two groups: one gets the lifestyle program alone for 6 months, the…

This pilot study tests a structured program to help young adults (ages 18-35) recently diagnosed with bipolar disorder transition from hospital to community care. The program includes group education sessions and one-on-one peer support over several months. Researchers want to se…

This study tests whether giving pregnant people at risk of preterm birth half the usual dose of a steroid (Celestone) works as well as the full dose to prevent serious health problems in their babies. About 3,250 participants will receive either one or two doses after an initial …

This study collects information from 150 adults with antiphospholipid syndrome who had an artery clot in the past year. Participants are already on one of four blood-thinning treatments. Researchers will track who has another clot or a major bleed over two years to see which trea…

This study compares surgery (arthroscopic stabilization) to non-surgical care for people who have dislocated their shoulder for the first time. Researchers will track 100 participants aged 14 to 40 over two years to see which approach leads to fewer repeat dislocations and better…

This pilot study compares two surgical techniques for repairing damaged hip cartilage in 40 people aged 18 to 55. One group receives standard microfracture surgery, while the other gets an enhanced procedure called AMIC, which uses a collagen patch to protect the repair site. Res…

This study tests whether a safe, non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve working memory in people with dementia. The stimulation is timed to each person's brain waves, measured by EEG, to help brain regions communicate b…

This study tests whether a virtual therapy guided by parents can help teens with anorexia nervosa while reducing long wait times for treatment. About 90 families will take part, with parents leading sessions using a structured program. The goal is to see if this approach eases sy…

This study tests a virtual health coaching program for adults with type 2 diabetes who also face mental health challenges like anxiety or diabetes distress. Participants receive weekly coaching calls, support from a care team, and online tools to help manage both conditions. The …

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests a 10-week power exercise program for people who had a stroke at least 6 months ago. Researchers want to see if it improves walking, strength, and balance better than standard strength training. Sixty participants will be randomly assigned to either the power prog…

This study tests whether analyzing a patient's phlegm can help doctors choose better treatments for chronic cough in interstitial lung disease (ILD). About 120 adults with ILD and daily cough for at least 8 weeks will be randomly assigned to either phlegm-guided treatment or stan…

This pilot study tests whether a single dose of potassium sorbate, a common food preservative, changes how much people with obesity eat over 24 hours. Twenty adults will receive either the preservative or a placebo, then switch after a break. The main goal is to see if the study …

This study tests a virtual training program called ABCs that teaches healthcare providers how to have better conversations with patients about serious illness. The program includes online modules and live workshops. Researchers will compare providers who receive the training righ…

This observational study will use CT scans to measure mucus plugging in the airways of people with asthma, COPD, or chronic cough, and compare them to healthy volunteers. Researchers hope to understand how mucus changes over time and find biomarkers that could guide treatment. Th…

This pilot study tests whether a physiotherapist navigator can help cancer patients manage side effects like fatigue and strength loss during treatment. 26 adults recently diagnosed with cancer will either receive usual care or meet with the navigator for six sessions over 12-18 …

This pilot study tests better ways to recruit a wider range of people into stroke rehabilitation research, especially women and those with aphasia (trouble speaking or understanding language). Researchers will compare a new, more supportive recruitment approach to the usual metho…

This study looks at how different types of hormonal birth control affect the way young, healthy women process sugar. Researchers will compare three groups: women not on birth control, those taking birth control pills, and those using an IUD. Participants will drink a sugary solut…

This study is for adults with asthma whose symptoms don't improve with standard inhalers. Researchers will use advanced MRI and CT scans to see if structural problems in the airways—like narrowing or mucus plugs—prevent inhaled medications from reaching the lungs. Participants wi…