Can morphine or pregabalin finally stop that nagging cough?

NCT ID NCT07288528

Not yet recruiting Symptom relief Sponsor: McMaster University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two common nerve-pain drugs (low-dose morphine and pregabalin) and a virtual cough-control therapy, alone or together, in 124 adults with chronic cough that hasn't improved with standard treatments. The goal is to see which approach best reduces coughing frequency over 6 weeks. Participants will be randomly assigned to one of four treatment combinations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-dose morphine, pregabalin, and virtual cough control therapy
What this could lead to: If successful, this trial could provide effective, well-tolerated options to reduce coughing in people with chronic cough that hasn't responded to other treatments.
What could go wrong: This is a relatively small, early-phase trial, so results may not apply to everyone. Both morphine and pregabalin can cause side effects like drowsiness or dizziness, and the virtual therapy may not work for all patients.

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Conditions

The condition(s) this trial relates to.

Chronic Cough Cough cough hypersensitivity syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC COUGH COUGH COUGH HYPERSENSITIVITY SYNDROME REFRACTORY CHRONIC COUGH UNEXPLAINED CHRONIC COUGH

Contacts and locations

Locations

Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke

Sherbrooke, Quebec, J1H 5N4, Canada
Institut universitaire de cardiologie et de pneumologie de Quebec - University Laval

Québec, Quebec, G1V 4G5, Canada
Respiratory Clinical Trials Centre, University of Calgary

Calgary, Alberta, T2N 4Z6, Canada
Respiratory Research Lab, McMaster University

Hamilton, Ontario, L8N 3Z5, Canada
St Joseph's Health Care London

London, Ontario, N6A 4V2, Canada

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