Can morphine or pregabalin finally stop that nagging cough?
NCT ID NCT07288528
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two common nerve-pain drugs (low-dose morphine and pregabalin) and a virtual cough-control therapy, alone or together, in 124 adults with chronic cough that hasn't improved with standard treatments. The goal is to see which approach best reduces coughing frequency over 6 weeks. Participants will be randomly assigned to one of four treatment combinations.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
low-dose morphine, pregabalin, and virtual cough control therapy
What this could lead to
If successful, this trial could provide effective, well-tolerated options to reduce coughing in people with chronic cough that hasn't responded to other treatments.
What could go wrong
This is a relatively small, early-phase trial, so results may not apply to everyone. Both morphine and pregabalin can cause side effects like drowsiness or dizziness, and the virtual therapy may not work for all patients.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, J1H 5N4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut universitaire de cardiologie et de pneumologie de Quebec - University Laval
Québec, Quebec, G1V 4G5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Respiratory Clinical Trials Centre, University of Calgary
Calgary, Alberta, T2N 4Z6, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Respiratory Research Lab, McMaster University
Hamilton, Ontario, L8N 3Z5, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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St Joseph's Health Care London
London, Ontario, N6A 4V2, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••