New pill aims to silence chronic cough that Won't quit

NCT ID NCT05599191

Completed Symptom relief Sponsor: Bellus Health Inc. - a GSK company Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study tests an experimental drug called BLU-5937 (camlipixant) in adults with refractory chronic cough, including unexplained chronic cough, that has lasted at least a year. Participants take the drug or a placebo daily for 52 weeks to see if it reduces coughing frequency and severity. The trial also monitors safety, including any taste changes or mouth numbness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental drug called BLU-5937 (camlipixant) taken as a tablet
What this could lead to: If successful, this could provide a new treatment option for people with chronic cough that does not respond to other therapies.
What could go wrong: This is an early Phase 3 trial, so the drug may not prove effective or safe in the long term. Possible side effects include taste disturbances and mouth numbness.

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Conditions

The condition(s) this trial relates to.

Chronic Cough Cough Respiration Disorders respiratory system disorder Signs and Symptoms, Respiratory

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COUGH REFRACTORY CHRONIC COUGH

Contacts and locations

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Locations

GSK Investigational Site

Jasper, Alabama, 35501, United States
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Litchfield Park, Arizona, 85340, United States
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Scottsdale, Arizona, 85248, United States
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Little Rock, Arkansas, 72205, United States
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Encinitas, California, 92024, United States
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Mission Viejo, California, 92691, United States
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Paramount, California, 90723, United States
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Roseville, California, 95661, United States
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Aurora, Colorado, 80012, United States
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Colorado Springs, Colorado, 80923, United States
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Clearwater, Florida, 33756, United States
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Gainesville, Florida, 32608, United States
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Miami, Florida, 15801, United States
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Miami, Florida, 33155, United States
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Miami, Florida, 33173, United States
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Miami, Florida, 33186, United States
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Orlando, Florida, 32713, United States
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Lawrenceville, Georgia, 30046, United States
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Normal, Illinois, 61761, United States
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Oak Lawn, Illinois, 60453, United States
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Ames, Iowa, 50010, United States
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Iowa City, Iowa, 52242, United States
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Kansas City, Kansas, 66160, United States
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Topeka, Kansas, 66606, United States
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Wichita, Kansas, 67214, United States
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Crowley, Louisiana, 70526, United States
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Shreveport, Louisiana, 71115, United States
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Annapolis, Maryland, 21404, United States
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North Dartmouth, Massachusetts, 02747, United States
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Ann Arbor, Michigan, 48109, United States
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Ypsilanti, Michigan, 48197, United States
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Columbia, Missouri, 65203, United States
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St Louis, Missouri, 63110, United States
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St Louis, Missouri, 63141, United States
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Missoula, Montana, 59808, United States
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Jersey City, New Jersey, 07304, United States
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The Bronx, New York, 10461, United States
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Charlotte, North Carolina, 28277, United States
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Raleigh, North Carolina, 28401, United States
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Rocky Mount, North Carolina, 27804, United States
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Salisbury, North Carolina, 28144, United States
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Winston-Salem, North Carolina, 27103, United States
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Columbus, Ohio, 43215, United States
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Dayton, Ohio, 45417, United States
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Oklahoma City, Oklahoma, 73104, United States
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Tulsa, Oklahoma, 74136, United States
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Medford, Oregon, 97504, United States
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Portland, Oregon, 97202, United States
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Philadelphia, Pennsylvania, 19140, United States
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Warwick, Rhode Island, 02886, United States
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Charleston, South Carolina, 29406, United States
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Little River, South Carolina, 29566, United States
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Mt. Pleasant, South Carolina, 29464, United States
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Rock Hill, South Carolina, 29732, United States
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Bristol, Tennessee, 37620, United States
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Knoxville, Tennessee, 37938, United States
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Dallas, Texas, 75231-4307, United States
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Houston, Texas, 77074, United States
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Houston, Texas, 77401, United States
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McKinney, Texas, 75069, United States
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San Antonio, Texas, 78229, United States
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Waco, Texas, 76712, United States
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Salt Lake City, Utah, 84132, United States
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Norfolk, Virginia, 23507, United States
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Williamsburg, Virginia, 23188, United States
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Bellevue, Washington, 68123, United States
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Bellingham, Washington, 98225, United States
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Buenos Aires, C1406AGA, Argentina
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Buenos Aires, C199AAB, Argentina
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Ciudad Autonoma Buenos Aires, C1128AAF, Argentina
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Ciudad Autonoma de Bueno, C1027AAP, Argentina
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Córdoba, X5003DCE, Argentina
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Mar del Plata, B7600FYK, Argentina
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Mendoza, 5500, Argentina
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Rosario, S2000DBS, Argentina
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Rosario, S2000DEJ, Argentina
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Rosario, S2002OJN, Argentina
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San Miguel de Tucumán, T4000IAI, Argentina
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Santa Fe, 3000, Argentina
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Vicente López, 1602, Argentina
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Brussels, 1200, Belgium
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Ghent, 9000, Belgium
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Kortrijk, 8500, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Mechelen, 2800, Belgium
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Roeselare, 8800, Belgium
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Calgary, Alberta, T2T 5C7, Canada
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Calgary, Alberta, T3E 7M8, Canada
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Kelowna, British Columbia, V1Y3H5, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Hamilton, Ontario, L8M 1K7, Canada
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Hamilton, Ontario, L8N 3Z5, Canada
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Toronto, Ontario, M5T 3A9, Canada
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Windsor, Ontario, N8X 1T3, Canada
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Greenfield Park, Quebec, J4V 2H1, Canada
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Montreal, Quebec, H1M 1B1, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1N 4V3, Canada
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Québec, Quebec, G1V 4G5, Canada
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Québec, Quebec, G1V 4W2, Canada
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Québec, Quebec, G3K 2P8, Canada
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Saint-Charles-Borromée, Quebec, J6E 2B4, Canada
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Sherbrooke, Quebec, J1H 5N4, Canada
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Trois-Rivières, Quebec, G8T 7A1, Canada
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Victoriaville, Quebec, G6P 6P6, Canada
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Burlington, ON L7N 3V2, Canada
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Floridablanca, 681004, Colombia
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Medellín, 00000, Colombia
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Medellín, 050034, Colombia
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Medellín, 50021, Colombia
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Dijon, 21079, France
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Lille, 59037, France
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Marseille, 13003, France
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Marseille, 13015, France
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Montpellier, 34295, France
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Paris, 75014, France
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Strasbourg, 67091, France
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Toulouse, 31000, France
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Balatonfüred, 8230, Hungary
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Budapest, 1027, Hungary
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Budapest, 1033, Hungary
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Gödöllő, 2100, Hungary
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Hajdúnánás, 4080, Hungary
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Mosonmagyaróvár, 9300, Hungary
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Pécs, 7635, Hungary
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Püspökladány, 4150, Hungary
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Aurangabad, 431003, India
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Bengaluru, 560068, India
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Bikaner, 334001, India
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Delhi, 110076, India
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Jaipur, 302023, India
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Kolkata, 700027, India
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Kozhikode, 673008, India
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Nashik, 422007, India
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Nashik, 422009, India
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Pune, 411004, India
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Rohtak, 124514, India
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Thane, 401107, India
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Ulhasnagar, 421001, India
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Hadera, 169, Israel
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Haifa, 3436212, Israel
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Jerusalem, 9112001, Israel
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Petah Tikva, 4941492, Israel
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Ramat Gan, 52621, Israel
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Tel Aviv, 64239, Israel
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Alkmaar, 1815 JD, Netherlands
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Arnhem, 6815 AD, Netherlands
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Breda, 4818 CK, Netherlands
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Eindhoven, 5623 EJ, Netherlands
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Uden, 5406 PT, Netherlands
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Zutphen, 7207 AE, Netherlands
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Zwolle, 8025 AB, Netherlands
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Bialystok, 15-010, Poland
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Bydgoszcz, 85-079, Poland
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Bydgoszcz, 85-796, Poland
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Lodz, 90-141, Poland
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Lodz, 90-153, Poland
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Ostrowiec Świętokrzyski, 27-400, Poland
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Piaseczno, 05-500, Poland
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Rzeszów, 35-051, Poland
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Tarnów, 33-100, Poland
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Zawadzkie, 47-120, Poland
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Bloemfontein, 9301, South Africa
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Durban, 4001, South Africa
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Durban, 4093, South Africa
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George, 6529, South Africa
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Johannesburg, 1501, South Africa
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Johannesburg, 2001, South Africa
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Johannesburg, 2060, South Africa
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Pretoria, 0122, South Africa
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Somerset West, 7130, South Africa
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Alcobendas, 28100, Spain
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Badalona, 08916, Spain
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Barcelona, 08017, Spain
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Barcelona, 08025, Spain
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Barcelona, 08036, Spain
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Granada, 18014, Spain
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Madrid, 28006, Spain
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Madrid, 28007, Spain
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Málaga, 29004, Spain
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Málaga, 29010, Spain
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Pamplona, 31008, Spain
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Pozuelo de Alarcón, 28223, Spain
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Santiago de Compostela, 15706, Spain
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Istanbul, 34020, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Izmir, 35110, Turkey (Türkiye)
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Mersin, 33343, Turkey (Türkiye)
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Belfast, BT9 7AB, United Kingdom
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Bristol, BS374AX, United Kingdom
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Corby, NN17 2UR, United Kingdom
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Hayle, TR27 5DT, United Kingdom
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Hull, HU12 8JD, United Kingdom
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London, SW3 6HP, United Kingdom
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Northwood, HA6 2RN, United Kingdom
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Orpington, BR5 3QG, United Kingdom
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Shipley, BD18 3SA, United Kingdom
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Wishaw, ML2 0DP, United Kingdom
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Wythenshawe, M23 9LT, United Kingdom

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