Chili compound put to the test as a cough silencer

NCT ID NCT04125563

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether taking capsaicin, the compound that gives chili peppers their heat, can desensitize the cough reflex and reduce symptoms in people with chronic idiopathic cough, a persistent cough with no identifiable cause. About 55 adults with this condition will receive either capsaicin capsules or a placebo for four weeks, then switch after a two-week break. Researchers will measure cough sensitivity and use a cough monitor to see if the treatment reduces coughing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Capsaicin (from chili extract) taken as oral capsules
What this could lead to
If it works, this could point toward a new treatment for chronic idiopathic cough, a condition with no clear cause and few effective options.
What could go wrong
This is a small, early-stage trial, so results may not hold up in larger studies. Capsaicin can cause stomach irritation or burning sensations, and it may not reduce coughing in everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

55 people

The number who actually took part.

Started

Jun 2019

Finished

Aug 2022

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Out-patients, men and women * Age 18-75 years * Present non-smoker * A diagnosis of CIC, set by a trained specialised physician * Exceeding the cut off limit for the Swedish version of the Hull Airway Reflux Questionnaire (HARQ-S): (a total score of ≥13 points) * At screening visit reporting daily, troublesome coughing and an easily evoked cough reflex since at least two months * At screening visit having a positive capsaicin inhalation cough test Exclusion Criteria: * Known or suspected chili allergy * Known or suspected allergy to the colorant Tartrazine (FD\&C Yellow #6) * Any kind of diabetes * Treatment the preceding month with any kind of chili medication or food supplement containing capsaicin or having a diet including chili in treatment purpose * Treatment the preceding month with medication according to the study protocol * Pregnancy, breast-feeding, planned pregnancy during the study and fertile women not using acceptable contraceptive measures, as judged by the investigator * Suspected poor capability to follow instructions of the study, e.g. because of a history of drug abuse, difficult to read and/or understand Swedish or any other reason, as judged by the investigator * Airway infection the last 4 weeks before study start * Any significant disease or disorder which, in the opinion of the investigator, may either put the patient at risk because of participation in the study, or influence the results of the study, or the patient's ability to participate in the study * Any clinically relevant abnormal findings in physical examination, vital signs at baseline visit, which, in the opinion of the investigator, may put the patient at risk because of his/her participation in the study * Previous randomisation of treatment in the present study * Participation in another clinical study 30 days prior to and during this study * Smoking during the last ten years or/and \>10 pack years * Known alcohol and/or drug abuse * The participants will be asked for any season allergy or other allergy and for allergen exposure. The study start date will be adjusted to season or another possible allergen exposure.

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Conditions

The condition(s) this trial relates to.

Cough cough hypersensitivity syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Allergy clinic, Sahlgrenska University Hospital

    Gothenburg, Västra Götaland County, 413 45, Sweden

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