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Timing the dose: a new strategy to stop coughing under anesthesia?

NCT ID NCT07778953

Disease control Sponsor: Shiyou Wei Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial investigates whether the speed of giving sufentanil, a common opioid used during anesthesia, can prevent the cough that sometimes happens when the drug is injected. Researchers will test different infusion times in younger and older adults undergoing surgery with general anesthesia. The goal is to find the infusion time that prevents coughing in 90% of patients, which could make anesthesia induction smoother and more comfortable.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sufentanil citrate, an opioid painkiller, given by IV pump during anesthesia induction.
What this could lead to
If successful, this could identify the optimal infusion time for sufentanil to reduce coughing during anesthesia, improving comfort and safety for patients undergoing surgery.
What could go wrong
This is an early-phase, single-center study with a modest sample size. The results may not apply broadly, and the optimal infusion time might not significantly reduce cough in all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I-III * Aged ≥18 ears old * Scheduled for elective surgery requiring general anesthesia with tracheal intubation Exclusion Criteria: * Resting vital signs upon operating-room arrival: systolic blood pressure ≥160 mmHg, or diastolic blood pressure ≥100 mmHg, or heart rate ≥110 beats per minute. * Anticipated difficult airway, requirement for rapid-sequence induction, or emergency surgery. * Chronic cough, asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, active pulmonary disease, or upper respiratory tract infection within the preceding 2 weeks. * Regular opioid use for more than 2 weeks within 6 months before surgery; or recent use of antitussive agents or other medications that may alter the cough reflex. * Known history of allergy to study drug (sufentanil citrate). * Pregnancy, lactation, psychiatric disorders, or individuals unable to communicate appropriately.

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Conditions

The condition(s) this trial relates to.

Cough

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cough

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Shaoyang University Affiliated First Hospital

    Shaoyang, Hunan, 422000, China

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