New cough drug candidate camlipixant tested in healthy volunteers
NCT ID NCT07684586
First seen Jul 06, 2026 · Last updated Sep 01, 2026 · Updated 4 times
Summary
This phase 1 study tests camlipixant, a potential treatment for chronic cough, in 28 healthy adults. Researchers want to see how the body absorbs and processes different versions of the drug, and how food affects it. The main goal is to check safety and tolerability while measuring drug levels in the blood.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- camlipixant
- What this could lead to
- If successful, this study could help develop a more effective formulation of camlipixant for treating chronic cough.
- What could go wrong
- This is an early phase 1 study with only 28 healthy participants, so results may not predict effects in patients with cough. The drug may still fail in later trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Started
-
Jul 2026
- Expected to finish
-
Aug 2027
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 55 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participants who are healthy as determined by the investigator or medically qualified designee based on a medical evaluation including medical history, physical examination, clinical laboratory tests, vital sign measurements, and 12-lead Electrocardiogram (ECG). * Body weight greater than or equal (\>=) 50 kilogram (kg) and body mass index (BMI) within the range 18.5 to 32.0 kilogram per meter square (kg/m\^2) (inclusive). * A female participant is eligible to participate if they are not pregnant or breastfeeding, and one of the following conditions applies: i. Is a participant of non-childbearing potential (PONCBP) as defined in the full protocol. OR ii. Is a participant of childbearing potential (POCBP) and using a contraceptive method that is highly effective (with a failure rate of less than \[\<\] 1 percent \[%\], per year * Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol. * Must be willing and able to comply with the protocol. Exclusion Criteria: * History or presence of clinically significant cardiovascular, respiratory, hepatic, renal, gastrointestinal, biliary (including gallstones or previous cholecystectomy), endocrine, hematologic, or neurological disorders capable of significantly altering the absorption, distribution, metabolism, or elimination of drugs; constituting a risk when taking the study intervention or interfering with the interpretation of data. * Evidence of current SARS-CoV-2, confirmed by antigen testing, prior to admission in each period. * Alanine transaminase (ALT) \>1.0x Upper limit of normal (ULN) * Total bilirubin \>1.0 x ULN. Participants with Gilbert's syndrome are excluded. * QT interval corrected for heart rate according to Fridericia's formula (QTcF) \>450 millisecond (msec) * Participants with abnormal 12-lead ECG findings considered clinically significant by the investigator or designee at the screening visit.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Cough are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
GSK Investigational Site
Nottingham, Nottinghamshire, NG11 6JS, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could skipping the breathing tube ease recovery after throat surgery?
- Chili compound put to the test as a cough silencer
- Timing the dose: a new strategy to stop coughing under anesthesia?
- Can a simple breathing test unlock the secrets of chronic cough?
- Could a new dissolving tablet quiet coughs? safety trial begins
- New pill aims to silence chronic cough that Won't quit