New cough drug candidate camlipixant tested in healthy volunteers

NCT ID NCT07684586

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Sep 01, 2026 · Updated 4 times

Summary

This phase 1 study tests camlipixant, a potential treatment for chronic cough, in 28 healthy adults. Researchers want to see how the body absorbs and processes different versions of the drug, and how food affects it. The main goal is to check safety and tolerability while measuring drug levels in the blood.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
camlipixant
What this could lead to
If successful, this study could help develop a more effective formulation of camlipixant for treating chronic cough.
What could go wrong
This is an early phase 1 study with only 28 healthy participants, so results may not predict effects in patients with cough. The drug may still fail in later trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Started

Jul 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants who are healthy as determined by the investigator or medically qualified designee based on a medical evaluation including medical history, physical examination, clinical laboratory tests, vital sign measurements, and 12-lead Electrocardiogram (ECG). * Body weight greater than or equal (\>=) 50 kilogram (kg) and body mass index (BMI) within the range 18.5 to 32.0 kilogram per meter square (kg/m\^2) (inclusive). * A female participant is eligible to participate if they are not pregnant or breastfeeding, and one of the following conditions applies: i. Is a participant of non-childbearing potential (PONCBP) as defined in the full protocol. OR ii. Is a participant of childbearing potential (POCBP) and using a contraceptive method that is highly effective (with a failure rate of less than \[\<\] 1 percent \[%\], per year * Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol. * Must be willing and able to comply with the protocol. Exclusion Criteria: * History or presence of clinically significant cardiovascular, respiratory, hepatic, renal, gastrointestinal, biliary (including gallstones or previous cholecystectomy), endocrine, hematologic, or neurological disorders capable of significantly altering the absorption, distribution, metabolism, or elimination of drugs; constituting a risk when taking the study intervention or interfering with the interpretation of data. * Evidence of current SARS-CoV-2, confirmed by antigen testing, prior to admission in each period. * Alanine transaminase (ALT) \>1.0x Upper limit of normal (ULN) * Total bilirubin \>1.0 x ULN. Participants with Gilbert's syndrome are excluded. * QT interval corrected for heart rate according to Fridericia's formula (QTcF) \>450 millisecond (msec) * Participants with abnormal 12-lead ECG findings considered clinically significant by the investigator or designee at the screening visit.

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Conditions

The condition(s) this trial relates to.

Chronic Cough Cough

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • GSK Investigational Site

    Nottingham, Nottinghamshire, NG11 6JS, United Kingdom

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