New study aims to uncover why some kids with high blood pressure develop heart and kidney problems

NCT ID NCT04752293

Recruiting now Knowledge-focused Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is looking at children ages 7 to 18 who have been newly diagnosed with high blood pressure. Researchers want to understand how certain hormones in the body, like angiotensin-(1-7), may contribute to damage in the heart, kidneys, and blood vessels. Over two years, they will collect blood and urine samples and measure blood pressure and organ function. The goal is to learn why some children develop complications, which could lead to better treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal new targets for treating or preventing heart and kidney damage in children with high blood pressure.
What could go wrong: This is an observational study, not a treatment trial. It will not directly test any new drug or therapy. Results may take years to translate into clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury Albuminuria essential hypertension hypertensive disorder Hypertrophy, Left Ventricular Hyperuricemia impaired renal function disease kidney disorder left ventricular failure obesity disorder Pediatric Obesity primary dysautonomia proteinuria Ventricular Dysfunction, Left

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALBUMINURIA ANGIOTENSIN HYPERTENSION AUTONOMIC DYSFUNCTION AUTONOMIC IMBALANCE BLOOD PRESSURE DISORDERS HYPERTENSION KIDNEY DISEASES KIDNEY DYSFUNCTION KIDNEY INJURY LEFT ATRIAL DILATATION LEFT VENTRICULAR DIASTOLIC DYSFUNCTION LEFT VENTRICULAR DYSFUNCTION LEFT VENTRICULAR HYPERTROPHY PEDIATRIC KIDNEY DISEASE PEDIATRIC OBESITY PROTEINURIA SODIUM URINE HIGH URIC ACID RETENTION

Contacts and locations

Locations

Wake Forest Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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