New drug shows promise for kidney disease patients

NCT ID NCT04663204

Recruiting now Disease control Sponsor: University of Leicester Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a drug called sparsentan in 24 adults with IgA nephropathy, a kidney disease. Some participants are newly diagnosed, others have the disease return after a kidney transplant. The goal is to see if sparsentan can reduce protein in the urine, a sign of kidney damage, and protect kidney function over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sparsentan
What this could lead to: If successful, sparsentan could offer a new treatment option to slow kidney damage in people with IgA nephropathy, potentially delaying or avoiding dialysis or transplant.
What could go wrong: This is a small, early-phase trial with only 24 participants, so results may not apply to everyone. The drug may not work as hoped or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune disease glomerulonephritis IgA glomerulonephritis IgA nephropathy, susceptibility to, 1 immune system disorder kidney disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE DISEASES GLOMERULONEPHRITIS GLOMERULONEPHRITIS, IGA IMMUNE SYSTEM DISEASES IMMUNOGLOBULIN A NEPHROPATHY KIDNEY DISEASES

Contacts and locations

Locations

Cambridge University Hospitals NHS Trust
RECRUITING

Cambridge, England, United Kingdom
King's College Hospital
RECRUITING

London, United Kingdom
Leicester General Hospital, University Hospitals of Leicester NHS Trust
RECRUITING

Leicester, LE5 4PW, United Kingdom
Northern Care Alliance NHS Foundation Trust - Salford Royal
RECRUITING

Salford, England, United Kingdom
Royal Infirmary of Edinburgh & Western General Hospital
RECRUITING

Edinburgh, Scotland, United Kingdom
University Hospital of wales
RECRUITING

Cardiff, Wales, CF14 4XW, United Kingdom

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