New hope for lung cancer patients whose current drug stops working

NCT ID NCT05261399

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study tests whether adding savolitinib to osimertinib works better than chemotherapy for people with a certain type of advanced lung cancer (EGFR-mutated, MET-positive) that has stopped responding to osimertinib. About 345 adults will be randomly assigned to receive either the drug combo or chemotherapy. The main goal is to see how long the cancer stays under control.

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Conditions

The condition(s) this trial relates to.

carcinoma Neoplasm Metastasis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA NON-SMALL-CELL LUNG

Contacts and locations

Locations

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Orlando, Florida, 32804, United States
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Honolulu, Hawaii, 96819, United States
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New Brunswick, New Jersey, 08903, United States
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New York, New York, 10032, United States
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Nashville, Tennessee, 37232, United States
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Buenos Aires, C1125ABD, Argentina
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CABA, C1019ABS, Argentina
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Florida, B1602DQD, Argentina
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La Rioja, F5300COE, Argentina
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Rosario, 2000, Argentina
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Rosario, 2123, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Viedma, R8500ACE, Argentina
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Fremantle, 6160, Australia
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Southport, 4215, Australia
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Waratah NSW, 2298, Australia
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Westmead, 2145, Australia
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Brussels, 1000, Belgium
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Ghent, 9000, Belgium
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Roeselare, 8800, Belgium
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Belo Horizonte, 30110-022, Brazil
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Cachoeiro de Itapemirim, 29308-014, Brazil
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Ijuí, 98700-000, Brazil
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Porto Alegre, 90035-903, Brazil
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Porto Alegre, 90050-170, Brazil
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Salvador, 41253-190, Brazil
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Salvador, 41950-610, Brazil
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São Paulo, 04014-002, Brazil
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São Paulo, 04538-132, Brazil
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São Paulo, 04556-100, Brazil
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Vitória, 29043-260, Brazil
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H3T 1M5, Canada
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Santiago, 7500713, Chile
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Baoding, 71030, China
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Beijing, 100036, China
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Beijing, 101149, China
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Bengbu, 233004, China
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Changchun, 130012, China
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Changsha, 410011, China
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Changsha, 41003, China
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Chengdu, 610041, China
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Chongqing, 400016, China
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Fuzhou, 350001, China
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Fuzhou, 350011, China
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Hangzhou, 310022, China
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Harbin, 150040, China
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Hefei, 230031, China
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Jinan, 250022, China
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Linyi, 276000, China
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Nanchang, 330006, China
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Qingdao, 266035, China
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Shanghai, 200030, China
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Shenyang, 110001, China
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Shenzhen, 518020, China
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Wuhan, 430022, China
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Wuhan, 430079, China
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Xi'an, 710061, China
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Xi'an, 710100, China
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Xiangfan, 441021, China
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Yichang, 443003, China
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Zhengzhou, 450008, China
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Bobigny, 93000, France
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Brest, 29200, France
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Créteil, 94010, France
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Dijon, 21079, France
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Marseille, 13915, France
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Paris, 75005, France
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Poitiers, 86021, France
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Rennes, 35033, France
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Rouen, 76000, France
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Saint-Herblain, 44800, France
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Saint-Quentin, 02321, France
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Strasbourg, 67091, France
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Suresnes, 92151, France
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Berlin, 14165, Germany
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Chemnitz, 09113, Germany
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Frankfurt A. Main, 60590, Germany
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Gauting, 82131, Germany
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Immenhausen, 34376, Germany
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Löwenstein, 74245, Germany
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München, 81925, Germany
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Münster, 48149, Germany
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Wangen, 88239, Germany
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Athens, 115 27, Greece
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Athens, 11527, Greece
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Chaïdári, 124 62, Greece
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Heraklion, 71110, Greece
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Larissa, 41110, Greece
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Rio, 265 04, Greece
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Thessaloniki, 546 39, Greece
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Thessaloniki, 54622, Greece
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Hong Kong, 999077, Hong Kong
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Kowloon, Hong Kong
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Afula, 18341, Israel
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Ashdod, 7747629, Israel
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Be’er Ya‘aqov, 70300, Israel
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Hadera, 38100, Israel
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Jerusalem, 91031, Israel
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Tel Aviv, 6423906, Israel
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Avellino, 83100, Italy
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Aviano, 33081, Italy
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Catania, 95123, Italy
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Meldola, 47014, Italy
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Milan, 20133, Italy
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Milan, 20141, Italy
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Modena, 41124, Italy
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Monserrato, 09042, Italy
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Naples, 80138, Italy
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Orbassano, 10043, Italy
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Padova, 35128, Italy
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Parma, 43126, Italy
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Perugia, 6124, Italy
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Peschiera del Garda, 37019, Italy
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Roma, 00144, Italy
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Roma, 00152, Italy
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Treviso, 31100, Italy
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Bunkyō City, 113-8603, Japan
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Chūōku, 104-0045, Japan
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Fukuoka, 812-8582, Japan
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Hirosaki-shi, 036-8563, Japan
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Hiroshima, 730-8518, Japan
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Iwakuni-shi, 740-8510, Japan
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Kanazawa, 920-8641, Japan
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Kashiwa, 277-8577, Japan
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Kobe, 650-0017, Japan
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Kobe, 650-0046, Japan
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Kumamoto, 860-8556, Japan
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Kurume-shi, 830-0011, Japan
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Nagasaki, 852-8501, Japan
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Okayama, 700-8558, Japan
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Osaka, 534-0021, Japan
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Osakasayama-shi, 589-8511, Japan
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Sakaishi, 591-8555, Japan
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Sapporo, 003-0804, Japan
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Sapporo, 060-8638, Japan
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Sendai, 980-0873, Japan
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Sunto-gun, 411-8777, Japan
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Utsunomiya, 320-0834, Japan
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Wakayama, 641-8510, Japan
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Yokohama, 241-8515, Japan
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Kota Bharu, 15586, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Petaling Jaya, 47500, Malaysia
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Pulau Pinang, 10990, Malaysia
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Sabak Bernam, 88996, Malaysia
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Bacolod, 6100, Philippines
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Davao City, 8000, Philippines
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Manila, 1000, Philippines
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Quezon City, 1100, Philippines
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Quezon City, 1112, Philippines
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San Juan City, 1502, Philippines
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Lodz, 93-338, Poland
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Olsztyn, 10-357, Poland
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Singapore, 169610, Singapore
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Singapore, 308433, Singapore
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Goyang-si, 10408, South Korea
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Gyeonggi-do, 13620, South Korea
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Jinju, 660-702, South Korea
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Seoul, 06273, South Korea
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Seoul, 06351, South Korea
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Seoul, 08308, South Korea
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Seoul, 138-736, South Korea
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Seoul, 6591, South Korea
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Suwon, 16247, South Korea
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Badajoz, 6006, Spain
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Badalona, 8916, Spain
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Barcelona, 08036, Spain
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Barcelona, 8035, Spain
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Córdoba, 14004, Spain
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Girona, 17007, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Majadahonda, 28222, Spain
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Málaga, 29010, Spain
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Pontevedra, 36312, Spain
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Sabadell, 08208, Spain
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Seville, 41009, Spain
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Valencia, 46026, Spain
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Zaragoza, 50009, Spain
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Baden, CH-5405, Switzerland
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Zurich, 8063, Switzerland
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Chiayi City, 62247, Taiwan
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Hsinchu, 300, Taiwan
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Kaohsiung City, 83301, Taiwan
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Liuying, 736, Taiwan
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Taichung, 404, Taiwan
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Taichung, 40705, Taiwan
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Taipei, 100, Taiwan
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Taipei, 11259, Taiwan
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Taipei, 112, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10700, Thailand
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Chanthaburi, 22000, Thailand
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Chiang Mai, 50200, Thailand
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Dusit, 10300, Thailand
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Hat Yai, 90110, Thailand
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Muang, 40002, Thailand
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Adana, 1370, Turkey (Türkiye)
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Ankara, 6800, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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Istanbul, 34214, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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London, SE1 9RT, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Wolverhampton, WV10 0QP, United Kingdom
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Can Tho, 900000, Vietnam
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Hanoi, 100000, Vietnam
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Hanoi, 10000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam

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