New pill plus chemo shows promise for tough head and neck cancers

NCT ID NCT05283226

Recruiting now Disease control Sponsor: NATCO Pharma Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 2 trial is testing an oral drug called NRC-2694-A combined with the chemotherapy paclitaxel in people with recurrent or metastatic head and neck squamous cell carcinoma that has worsened after immunotherapy. About 21 adults will receive the combination to see if it shrinks tumors. The goal is to find a new option for patients who have run out of standard treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NRC-2694-A (an oral drug) combined with paclitaxel (a chemotherapy drug)
What this could lead to: If successful, this combination could offer a new treatment option for patients with advanced head and neck cancer that has stopped responding to immunotherapy.
What could go wrong: This is a small, early-phase trial with only 21 participants, so results may not apply broadly. The combination may cause side effects like those from chemotherapy, and there is no guarantee it will shrink tumors or extend survival.

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Conditions

The condition(s) this trial relates to.

carcinoma head and neck squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA RECURRENT AND/OR METASTATIC HEAD AND NECK SQUAMOUS CELL CARCINOMA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Basavatarakam Indo American Cancer Hospital & Research Institute
NOT_YET_RECRUITING

Hyderabad, Telangana, 500034, India

Contact Phone: •••-•••-•••• Email: •••••@•••••
Dartmouth Hitchcock Medical Center
COMPLETED

Lebanon, New Hampshire, 03756-1000, United States
Daycare Angels under AOH
RECRUITING

Mumbai, Maharashtra, 40001, India

Contact Phone: •••-•••-•••• Email: •••••@•••••
Grant Medical Foundation Ruby Hall Clinic
COMPLETED

Pune, Maharashtra, 411001, India
Los Angeles Hematology Oncology Medical Group
COMPLETED

Los Angeles, California, 90017, United States
Lynn Cancer Center
COMPLETED

Boca Raton, Florida, 33486, United States
Miami Cancer Center
COMPLETED

Miami, Florida, 33176, United States
Norton Cancer Institute - Downtown
COMPLETED

Louisville, Kentucky, 40202, United States
Providence Medical Foundation -Fullerton
COMPLETED

Fullerton, California, 92835, United States
Salib Oncology
COMPLETED

Easton, Pennsylvania, 18045, United States
University of Maryland Greenebaum Cancer Center
COMPLETED

Baltimore, Maryland, 21201-1544, United States
University of Wisconsin Carbone Cancer Center
COMPLETED

Madison, Wisconsin, 53792, United States
Washington University - Siteman Cancer Center
COMPLETED

St Louis, Missouri, 63110, United States

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