LUNG CANCER (NSCLC)

This study is testing a multi-step treatment plan for people with locally advanced non-small cell lung cancer that cannot be surgically removed. It combines chemotherapy, radiation, and two immunotherapy drugs designed to help the immune system fight cancer. The goal is to see if…

This study is testing whether a personalized immune cell therapy is safe for people with advanced non-small cell lung cancer. Doctors take a patient's own immune cells, grow large numbers of them in a lab, and then inject them back into the patient to help fight the cancer. The t…

This study is testing an inhaled therapy called KB707 for adults with advanced solid tumors in the lungs that have stopped responding to standard treatments. The therapy uses a modified, harmless virus designed to stimulate the immune system to fight the cancer directly in the lu…

This trial is for people with a specific type of advanced lung cancer (EGFR-mutated NSCLC) who have responded well to their first-line pill, osimertinib, but still have a few small, leftover cancer spots. It tests whether adding a targeted, high-dose radiation treatment (called l…

This study is testing a new oral medication called JBI-802, given alone or with an existing immunotherapy drug (pembrolizumab), for people with advanced non-small cell lung cancer that has a specific genetic change called an STK11 mutation. The main goals are to see if the treatm…

This early-stage study is testing a new drug called RMC-5127 in adults with advanced cancers that have a specific genetic change called KRAS G12V. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with other ca…

This early-stage study is testing a new way to treat a serious complication of lung cancer where it spreads to the lining of the brain and spinal cord. Doctors are injecting two cancer drugs directly into the spinal fluid to see if it is safe and if it helps patients live longer.…

This is the first-ever study in people of an experimental cancer drug called TJ101. The main goal is to find a safe dose and see how the body handles it. The study will also look for early signs that the drug can shrink tumors in adults with advanced cancers who have run out of s…

This is an early safety study testing an experimental drug called SH009 injection in adults with advanced solid tumors who have run out of standard treatment options. The study aims to find a safe dose, see how the body processes the drug, and check for early signs that it might …

This study is testing whether a drug called tislelizumab can help prevent early-stage lung cancer from coming back after surgery. It will involve about 108 adults who have had surgery to remove their cancer but are at higher risk of it returning. The main goal is to see if the dr…

This is the first study in people testing a new experimental cancer drug called PHN-012. It aims to find a safe dose and see if it can shrink tumors in patients with advanced colon, lung, or pancreatic cancer who have no other standard treatments left. The study will enroll about…

This study tests a personalized treatment for advanced non-small cell lung cancer patients who have exhausted standard options. Doctors collect immune cells from a patient's tumor, grow billions of them in a lab, then infuse them back into the patient to attack the cancer. The tr…

This study is testing a new blood test to see if it can find tiny amounts of leftover lung cancer cells after surgery, which could help predict if the cancer might come back. Researchers will track 30 patients who have had surgery for non-small cell lung cancer, taking blood samp…

This study aims to develop and test a new blood test that uses artificial intelligence to detect cancer early and monitor how well treatment is working. Researchers will analyze RNA from blood cells in 6,000 participants, including people with 8 common cancers and healthy individ…

This study is testing a new diagnostic platform that uses artificial intelligence to analyze small pieces of a patient's tumor. The goal is to predict whether a patient's cancer will respond to immunotherapy drugs before they start treatment. Researchers will compare the AI's pre…

This study is testing a new blood test to see if it can find tiny amounts of leftover cancer cells after a minimally invasive lung tumor treatment. Researchers will follow 30 patients who cannot have surgery, taking blood samples for two years to see if the test can predict cance…

This study is testing if a higher dose of a common steroid (dexamethasone) can better control pain after minimally invasive lung cancer surgery. It focuses on patients who are identified as being highly sensitive to pain before their operation. Researchers will compare a high dos…

This study is testing whether weekly phone calls from a trained support worker can improve the quality of life for Veterans with lung cancer. About 194 Veterans will be randomly assigned to either receive these support calls in addition to their usual care, or to receive only the…

This study aims to understand how air pollution causes serious diseases like lung cancer, COPD, and leukemia. Researchers will compare pollution levels found in the bodies of 300 non-smoking patients with these conditions to levels in healthy volunteers. The goal is to find new b…

This study is testing a short, 15-minute health survey for adults 65+ with early-stage lung cancer. The goal is to see if using this survey makes it easier for doctors to connect patients with helpful support services like physical therapy or nutrition counseling. Researchers wil…