LUNG CANCER (NSCLC)

This early-stage study tests a new drug called SH009 in about 150 people with advanced solid tumors (like liver, lung, or breast cancer) that have not responded to standard treatments. The main goal is to see if the drug is safe and can shrink tumors. Researchers will also measur…

This study tests a treatment that uses immune cells taken from a patient's own lung tumor. These cells are grown in large numbers and then put back into the patient to attack the cancer. The goal is to see if this approach can stop or slow the cancer from growing in 30 adults wit…

This study tests an inhaled treatment called KB707 for people with advanced solid tumors that have spread to the lungs. KB707 is a modified virus designed to trigger the immune system to attack cancer cells. The trial involves 250 adults who have not responded to standard treatme…

This early-stage study tests a new drug called RMC-5127 in adults with advanced solid tumors that have a specific KRAS G12V gene change. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. About 574 people with lung, colorectal, or panc…

This study tests whether adding local ablative therapy (like radiation) to the drug osimertinib can better control advanced EGFR-mutant lung cancer. About 64 adults with 3 or fewer remaining active tumor sites after initial drug treatment will be randomly assigned to continue osi…

This study tests an experimental drug called JBI-802, taken as a pill, alone or with another drug (pembrolizumab), in people with advanced lung cancer that has a specific gene change (STK11 mutation). The goal is to see if the treatment is safe and helps shrink or control the can…

This early-phase study tests whether specially grown immune cells (dendritic and natural killer cells) from a patient's own blood are safe for treating advanced non-small cell lung cancer. Ten participants who have already tried at least two standard treatments will receive the c…

This early-phase study tests whether injecting two drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe and helps control lung cancer that has spread to the lining of the brain. About 19 adults with this advanced condition will receive the treatment. The goal…

This early-stage study tests a new drug called PHN-012 in people with advanced colon, pancreatic, or lung cancers that have stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver a cancer-killing agent directly to tumor cells. The m…

This study tests a new treatment plan for people with advanced non-small cell lung cancer that cannot be removed by surgery. Participants will receive chemotherapy plus two immunotherapy drugs (PD-1 and CTLA-4 blockers), followed by chemoradiation, then more immunotherapy with ot…

This early-phase trial tests TJ101, an experimental antibody-drug conjugate, in adults with advanced solid tumors (lung, prostate, esophageal, and others) who have no standard treatment options left. The main goals are to find a safe dose and see if the drug can shrink tumors. Ab…

This study tests whether the immunotherapy drug tislelizumab, given after surgery, can help prevent early-stage lung cancer from coming back in people with high-risk features. About 108 adults with stage I non-small cell lung cancer that is 2-4 cm and has certain high-risk signs …

This study looks at whether giving veterans with lung cancer extra support can help them feel better day-to-day. Researchers will track quality of life, emergency room visits, and hospital stays over one year. The goal is to find simple ways to improve care for those who served.

This study tests whether a high dose of the steroid dexamethasone can reduce pain when coughing the morning after lung surgery. It includes 80 adults with lung cancer who are expected to have higher pain levels. Participants receive either a high or low dose of the drug during su…

This study looks at whether a short, 10-15 minute health check (called the Practical Geriatric Assessment) helps older adults with lung cancer get more support like nutrition advice or physical therapy before starting radiation. About 64 people aged 65 and older with early-stage …

This study is developing an AI-powered blood test to find cancer early and see how well treatments are working. Researchers will analyze blood samples from 6,000 adults with or without cancer to identify unique RNA signals in platelets and immune cells. The goal is a safe, non-in…

This study looks at whether a blood test measuring specific gene markers (SHOX2 and PTGER4) can find lung cancer early and track if it comes back after surgery. About 30 adults with non-small cell lung cancer will give blood samples before and after surgery for up to two years. T…

This study looks at whether measuring certain DNA markers (SHOX2 and PTGER4) in the blood can detect leftover cancer cells after a minimally invasive treatment called co-ablation for early-stage lung cancer. About 30 adults with non-small cell lung cancer who cannot have surgery …

This study tests whether advanced MRI scans can identify different immune environments inside lung tumors. Currently, this information requires a tissue biopsy. If successful, MRI could provide a non-invasive way to understand the tumor's immune status. The study will enroll 50 a…

This study looks at how air pollution particles get into the bodies of non-smokers with lung cancer, COPD, or leukemia, and compares them to healthy volunteers. Researchers will use advanced microscopes and chemical tests to find these particles in blood and tissue samples. The g…