Rigshospitalet, Denmark

This phase 3 trial tests whether rituximab, a cheaper drug, works as well as ocrelizumab for active multiple sclerosis. About 600 adults with relapsing or progressive MS will receive one of the two drugs. The main goal is to see if rituximab can prevent new brain lesions as effec…

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can safely treat bacterial endocarditis. Standard treatment lasts 4-6 weeks, but this study tests a personalized approach based on factors like fever and blood tests. The goal is…

This study tests whether closely monitoring arm swelling after breast cancer surgery and treating it early with a compression sleeve can prevent long-term lymphedema. 250 women who had many lymph nodes removed will be randomly assigned to either the monitoring program or usual ca…

This study looks at two types of hip implants used in total hip replacement for people with metastatic bone disease (cancer that has spread to the hip bone). The goal is to see if a newer implant design (dual mobility) is as good as a standard one (constrained liner) at preventin…

This study compares two minimally invasive treatments—microwave ablation and stereotactic body radiation therapy—for colorectal cancer that has spread to the liver. About 100 patients with 1 to 3 liver tumors that cannot be surgically removed will be randomly assigned to one of t…

This study looks at whether a 6-month exercise program (a mix of aerobic and resistance training) can improve fitness and reduce the risk of cancer coming back in patients who had surgery for colorectal cancer that spread to the liver. About 66 participants will be split into thr…

This study compares robot-assisted kidney transplant to the standard open surgery in 106 adults with end-stage kidney disease. The goal is to see if the robotic approach reduces serious complications like bleeding or blood clots within 30 days after surgery. Participants are rand…

This study tests whether two imaging tools—laser speckle contrast imaging (LSCI) and digital thermography—can objectively grade mesenteric traction syndrome (MTS), a frequent complication during abdominal surgery that causes low blood pressure, rapid heart rate, and facial flushi…

This study investigates whether cone-beam computed tomography (CBCT), a 3D imaging technique, can improve the diagnosis and surgical treatment of otosclerosis, a condition where abnormal bone growth in the middle ear causes hearing loss. Researchers will enroll 100 adults suspect…

Slow-flow vascular malformations — abnormal clusters of veins, capillaries, or lymph vessels — can cause pain, swelling, and appearance concerns. This study follows 60 children and adults who receive bleomycin electrosclerotherapy (BEST), a procedure that injects the drug bleomyc…

This study is investigating how common muscle loss, known as sarcopenia, is in people with blood cancers like leukemia, lymphoma, and myeloma. Researchers will measure body composition using DXA scans and track hospital stays, disease progression, and survival. The goal is to see…

This study follows adults with pathogenic variants in the anoctamin 5 gene, which causes a form of limb-girdle muscular dystrophy. Over three years, researchers will use whole-body MRI to measure changes in muscle fat content, and questionnaires to track fatigue and quality of li…

This study looks at whether measuring immune function before and after a solid organ transplant (kidney, heart, lung, liver, or pancreas) can predict the risk of infections and graft rejection. Researchers will profile the immune system of 188 transplant recipients at multiple ti…

This study aims to describe the pattern of muscle involvement in people with limb girdle muscular dystrophy caused by mutations in the anoctamin 5 gene. Researchers will collect and analyze MRI scans from 200 participants to see which muscles are affected and how much fat replace…

This study aims to find out how often cancer patients treated with opioids for pain are at risk of misusing these medications. Researchers will use two screening questionnaires to assess misuse risk in 200 adult outpatients receiving opioids for cancer-related pain. The findings …

This study looks at how doctors trust artificial intelligence (AI) when it estimates a baby's weight during pregnancy. Over 300 clinicians will review ultrasound cases and choose between AI-based or traditional weight estimates. Some doctors will also see how reliable the AI is. …

This study scans over 16,000 adults aged 18 to 70 without known heart disease to find hidden (silent) plaque in their arteries using ultrasound and CT scans. The goal is to measure how common silent atherosclerosis is and build a risk calculator that combines imaging, lifestyle, …

This study uses brain imaging to measure how LSD attaches to serotonin 2A receptors in the brain. Healthy volunteers receive a small dose of LSD, and researchers track how much of the drug reaches these receptors and how it relates to the intensity of the experience. The goal is …

This study follows 214 men treated for prostate cancer to see how many develop lower limb lymphedema (leg swelling) and who is most at risk. Participants attend check-ups every three months for 18 months. The goal is to better understand this side effect and its impact on quality…

This study follows 125 patients with incurable gastroesophageal cancer to measure how much muscle they lose during chemotherapy. Researchers will collect blood, tissue samples, and track treatment side effects and survival. The goal is to better understand why muscle wasting happ…

This study looks at whether high-intensity interval training (HIIT) can help regenerate lung tissue in people with COPD who are waiting for lung volume reduction surgery. 24 participants will be randomly assigned to either a HIIT exercise program or no exercise. Researchers will …

This study compares 16 people with mild-to-moderate COPD to 16 healthy volunteers matched by age, sex, and height. Researchers measure blood volume in the lungs and the whole body to see if a smaller lung blood volume contributes to exercise problems. No treatment is given—the go…

This study uses advanced full-body PET scans to see how the body handles sugar and amino acids in healthy people and those with non-alcoholic fatty liver disease (NAFLD). About 36 adults aged 18-70 will receive a radioactive tracer by mouth or IV and have scans to track nutrient …

This study follows 600 adult liver transplant recipients in Denmark for up to 10 years to understand why many develop heart, lung, kidney, or metabolic problems after transplant. Researchers will use scans, blood tests, and lung function tests to find risk factors. The goal is to…

This study looks at whether taking common painkillers like paracetamol or ibuprofen during pregnancy can affect a child's brain development, behavior, and language skills. Researchers will follow 685 children aged 2 to 4 years whose mothers were part of an earlier study on painki…

This study follows 144 blood cancer patients undergoing stem cell transplants to see how muscle function changes and whether it predicts complications like infections, relapse, or survival. Researchers will measure muscle mass and track medical events over time. The goal is to un…

This study looks at whether a blood test that finds HPV DNA can spot throat cancer coming back after treatment, possibly earlier than usual scans. Researchers will follow 200 patients with HPV-positive oropharyngeal cancer to see how accurate the test is. The goal is to improve m…

This study will follow 300 men with Klinefelter syndrome (an extra X chromosome) who are treated at a Danish hospital. Researchers will collect medical records, scans, and blood samples to map how the condition affects growth, hormones, fertility, heart health, and mental well-be…