Can a tailored antibiotic regimen shorten endocarditis treatment without risk?

NCT ID NCT03851575

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can safely treat bacterial endocarditis. Standard treatment lasts 4-6 weeks, but this study tests a personalized approach based on factors like fever and blood tests. The goal is to reduce hospital stays and associated risks while maintaining effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a personalized, shortened course of intravenous antibiotics
What this could lead to
If successful, this could shorten hospital stays and reduce risks like mental strain and loss of function for patients with endocarditis.
What could go wrong
This is a single-center trial, and the shorter course may not be as effective as standard treatment, potentially increasing the risk of complications.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Bispebjerg Hospital

    Copenhagen, Denmark

  • Brigham and Womens Hospital

    Boston, Massachusetts, 02115, United States

  • Gødstrup Regional Hospital

    Gødstrup, Denmark

  • Herlev Hoslpital

    Copenhagen, Denmark

  • Hillerød Hospital

    Hillerød, Denmark

  • Hvidovre Hospital

    Hvidovre, Denmark

  • Odense Sygehus

    Odense, 5000, Denmark

  • Rigshospitalet

    Copenhagen, Denmark, 2100, Denmark

  • Roskilde Sygehus, Zealand University hospital

    Roskilde, Denmark

  • Skejby Sygehus

    Aarhus, 8200, Denmark

  • Skåne University Hospital

    Lund, Sweden

  • Vejle Hospital

    Vejle, Denmark

  • Viborg Hospital

    Viborg, Denmark

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