Infective endocarditis

This study compares two common antibiotics, daptomycin and vancomycin, to see which one works better for adults with MRSA bloodstream infections. About 300 participants will be randomly assigned to one of the two drugs. The goal is to find which treatment leads to fewer complicat…

This study compares two antibiotic approaches for a serious heart valve infection caused by staph bacteria. One group gets a standard treatment that includes the drug rifampin, while the other group gets a treatment without it. The goal is to see if skipping rifampin is just as e…

This study compares oral antibiotics to intravenous (IV) antibiotics for treating infective endocarditis, a serious heart infection. Researchers want to see if taking pills at home works as well as getting IV treatment in a clinic. The trial involves 360 adults with specific type…

This phase 2 trial tests whether adding the antibiotic ertapenem to standard cefazolin treatment improves outcomes for adults with methicillin-susceptible Staphylococcus aureus bloodstream infections. About 60 participants will receive either the combination or a placebo. The stu…

This study looks at whether switching to the blood thinner dabigatran can improve outcomes for people with a serious staph bloodstream infection who are already taking other blood thinners. Researchers will compare those who switch to dabigatran with those who stay on their curre…

This study looks at whether switching from aspirin to clopidogrel (another blood thinner) can reduce heart complications in people with a serious staph bloodstream infection. About 300 adults already taking aspirin for heart disease will be randomly assigned to stay on aspirin or…

This study tests whether adding a special virus mixture (phage therapy) to standard antibiotics can improve outcomes for people with a serious heart valve infection called infective endocarditis. About 30 participants will receive either the phage therapy or a placebo alongside t…

This study looks at 330 adults with a serious heart valve infection (prosthetic valve endocarditis) caused by S. aureus bacteria. It compares the standard approach of giving the antibiotic rifampin against not giving it, to see if skipping it is just as safe and effective. The go…

This study tests whether replacing an infected heart device immediately after removal is as safe and effective as waiting for a later procedure. About 176 adults with device infections will be randomly assigned to either immediate or delayed reimplantation. The main goal is to se…

This study tests whether adding advanced molecular tests (like PCR and DNA sequencing) to standard blood cultures helps doctors identify the cause of infective endocarditis—a serious heart valve infection—more quickly. The goal is to see if this leads to more patients receiving t…

This study compares 3D cone beam CT scans to standard dental X-rays in 170 patients hospitalized for infective endocarditis, a serious heart infection. The goal is to see if the 3D scan detects more hidden mouth infections that could cause the heart infection to return. Participa…

This study is testing whether a special PET/CT scan using gallium-68 citrate can more accurately diagnose infections in artificial heart valves. Researchers will compare the scan results with the standard diagnosis after 3 months. The study involves 40 adults with suspected valve…

This study tests a new type of PET scan to see if it can better diagnose infections in artificial heart valves. Researchers will compare the scan results with standard tests in 30 adults who have a suspected valve infection. The goal is to improve accuracy and speed of diagnosis.

This trial investigates whether a professional dental cleaning and instruction on proper brushing and flossing can reduce the amount of bacteria that enter the bloodstream during tooth brushing. Such bacteria can sometimes lead to infective endocarditis, a serious infection of th…

This study is testing whether having a dental checkup before heart valve surgery can prevent serious complications like infection of the heart lining, repeat surgery, or death. About 1,300 adults scheduled for valve surgery will be randomly assigned to either get a dental screeni…

This study tests whether adding anemia treatment (iron, vitamins, and a hormone that boosts red blood cells) to standard care helps people with a serious heart valve infection feel better and walk farther. About 74 adults with both the infection and anemia will be enrolled. The g…

This registry collects detailed information from 1,000 patients with infective endocarditis, a serious heart infection. Researchers will track demographics, microbiology, imaging, and outcomes to understand current treatment effectiveness and guide future studies. The goal is to …

This study follows 645 patients hospitalized with infectious endocarditis, a serious heart infection. Researchers will track hospital deaths and long-term survival to identify factors that influence prognosis. The goal is to better understand how the disease progresses and what a…

This study is creating a large registry and biobank of 10,000 adults with various infections, such as bloodstream, heart, and bone infections. Researchers will collect medical data and biological samples to describe the infections and their treatments. The goal is to better under…

This study looks at how people recover after infective endocarditis, a serious heart infection. Researchers want to see if a 12-week exercise program can improve physical fitness, fatigue, and quality of life. About 50 adults who had the infection will take surveys, do interviews…

This study gathers information from 418 patients diagnosed with endocarditis, a serious heart infection. Researchers want to understand what factors lead to worse outcomes. No new treatments are tested—the goal is simply to learn from past and current patient experiences.

This study is collecting data from 150 patients with a serious heart infection called endocarditis. Researchers will measure antibiotic levels in the blood and use that information to build a computer model. The goal is to find the best dose for each patient, which could help mor…

This study looks at whether people with a staph bloodstream infection and a low risk score (VIRSTA score less than 3) can safely avoid a routine heart ultrasound. About 700 participants will be randomly assigned to either get the ultrasound or not. The goal is to see if skipping …

This study follows 700 patients with infective endocarditis, a serious heart infection, to gather real-world data on complications and outcomes. Researchers aim to improve treatment guidelines, which currently rely on expert opinion due to limited evidence. No new drug or treatme…

This study is creating a large national database of infective endocarditis, a serious heart infection. Researchers will collect information from 5,000 patients across France to understand the disease's causes, risk factors, and how it is currently treated. The goal is to improve …