Could skipping a common antibiotic be just as safe for heart infections?
NCT ID NCT07345325
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two antibiotic approaches for a serious heart valve infection caused by staph bacteria. One group gets a standard treatment that includes the drug rifampin, while the other group gets a treatment without it. The goal is to see if skipping rifampin is just as effective at preventing death within six months. The trial plans to enroll 422 adults with infected prosthetic heart valves.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rifampin
What this could lead to
If successful, this could show that a simpler antibiotic regimen without rifampin is just as effective, reducing side effects and drug interactions for patients with this heart infection.
What could go wrong
This is a non-inferiority trial, so it may only prove the rifampin-free regimen is not worse, not better. The infection is serious, and treatment failure could be life-threatening.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AP-HP hôpital St Antoine
NOT_YET_RECRUITINGParis, 75012, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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AP-HP, Groupe hospitalier Henri Mondor
NOT_YET_RECRUITINGCréteil, 94010, France
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Contact
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AP-HP, Hôpital Pitié Salpétrière
NOT_YET_RECRUITINGParis, 75013, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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AP-HP, hôpital Bichat-Claude Bernard
NOT_YET_RECRUITINGParis, 75018, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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CH Pau
RECRUITINGPau, 64000, France
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CH Tourcoing
RECRUITINGTourcoing, 59200, France
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CH intercommunal Cornouaille Quimper
NOT_YET_RECRUITINGQuimper, 29000, France
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CH metropole Savoie, Chambery, GHT Savoie-Belley, Site Aix les Bains
NOT_YET_RECRUITINGAix-les-Bains, 73100, France
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CHD Vendée
RECRUITINGLa Roche-sur-Yon, 85000, France
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CHR Orléans
NOT_YET_RECRUITINGOrléans, 45067, France
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CHU Angers
RECRUITINGAngers, 49933, France
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CHU Besançon
NOT_YET_RECRUITINGBesançon, 25030, France
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CHU Bordeaux, Cardiologic hospital of Haut lévêque
NOT_YET_RECRUITINGBordeaux, 33600, France
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Contact
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CHU Bordeaux, Haut Lévêque Hospital, Infectious disease department
NOT_YET_RECRUITINGBordeaux, 33600, France
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CHU Brest
RECRUITINGBrest, 29200, France
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CHU Dijon Bourgogne
RECRUITINGDijon, 21000, France
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CHU Grenoble
RECRUITINGGrenoble, 38043, France
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CHU Lyon, La Croix-Rousse Hospital, Infective disease department
NOT_YET_RECRUITINGLyon, 69317, France
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CHU Lyon, Louis Pradel Hospital, Cardiology Institute
NOT_YET_RECRUITINGLyon, 69677, France
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CHU Montpellier
NOT_YET_RECRUITINGMontpellier, 34090, France
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CHU Nancy
NOT_YET_RECRUITINGNancy, 54035, France
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CHU Nantes, Hôtel Dieu Hospital, Infective disease department
RECRUITINGNantes, 44093, France
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CHU Nantes, Laennec Hospital, Cardiology department
RECRUITINGNantes, 44800, France
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CHU Nice
RECRUITINGNice, 06202, France
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CHU Poitiers
RECRUITINGPoitiers, 86000, France
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CHU Rennes
NOT_YET_RECRUITINGRennes, 35000, France
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CHU St-Etienne
NOT_YET_RECRUITINGSaint-Etienne, 42270, France
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CHU Strasbourg
NOT_YET_RECRUITINGStrasbourg, 67000, France
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CHU Toulouse, Purpan Hospital, Infectious disease department
NOT_YET_RECRUITINGToulouse, 31059, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Toulouse, Rangueil Hospital, Cardiology department
NOT_YET_RECRUITINGToulouse, 31400, France
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CHU Tours
NOT_YET_RECRUITINGTours, 37044, France
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