Could tailored antibiotic doses save more endocarditis patients?

NCT ID NCT04647331

Recruiting now Knowledge-focused Sponsor: Uppsala University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is collecting data from 150 patients with a serious heart infection called endocarditis. Researchers will measure antibiotic levels in the blood and use that information to build a computer model. The goal is to find the best dose for each patient, which could help more people survive and avoid side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: beta-lactam antibiotics (ampicillin, penicillin G, cefotaxime, cloxacillin)
What this could lead to: If successful, this could lead to personalized antibiotic dosing for endocarditis patients, potentially improving survival and reducing side effects.
What could go wrong: This is an observational study, not a treatment trial. The model needs validation and may not improve outcomes in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endocarditis infective endocarditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFECTIVE ENDOCARDITIS

Contacts and locations

Locations

Karolinska University Hospital
NOT_YET_RECRUITING

Stockholm, Sweden
Sahlgrenska University Hospital
ACTIVE_NOT_RECRUITING

Gothenburg, Sweden
Skåne University Hospital
RECRUITING

Lund, Sweden
Uppsala University Hospital
RECRUITING

Uppsala, Sweden

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