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Pill power: oral antibiotics may match IVs for serious heart infection

NCT ID NCT05398679

Recruiting now Disease control Sponsor: Fundacion Clinic per a la Recerca Biomédica Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study compares oral antibiotics to intravenous (IV) antibiotics for treating infective endocarditis, a serious heart infection. Researchers want to see if taking pills at home works as well as getting IV treatment in a clinic. The trial involves 360 adults with specific types of infections and measures unplanned hospitalizations, deaths, relapses, and need for heart surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
antibiotics (oral and intravenous)
What this could lead to
If successful, this could allow many patients with infective endocarditis to switch from IV to oral antibiotics earlier, reducing hospital stays and improving quality of life.
What could go wrong
This is a non-inferiority trial, so it aims to show oral treatment is not worse than IV, not necessarily better. Results may not apply to all types of infections or patients, and there is a risk of relapse or complications.

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Conditions

The condition(s) this trial relates to.

endocarditis infective endocarditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOCARDITIS INFECTIVE

Contacts and locations

Locations

  • Hospital Bellvitge

    RECRUITING

    Barcelona, Barcelona, 08907, Spain

  • Hospital Clinic i Provincial de Barcelona

    RECRUITING

    Barcelona, Barcelona, 08036, Spain

  • Hospital General Universitario Gregorio Marañón

    RECRUITING

    Madrid, Madrid, 28007, Spain

  • Hospital General de Alicante

    RECRUITING

    Alicante, Alicante, 03010, Spain

  • Hospital Mútua de Terrassa

    RECRUITING

    Terrassa, Barcelona, 08221, Spain

  • Hospital Ramón y Cajal

    RECRUITING

    Madrid, Madrid, 28034, Spain

  • Hospital San Pedro

    RECRUITING

    Logroño, La Rioja, 26006, Spain

  • Hospital Sant Pau

    RECRUITING

    Barcelona, Barcelona, 08041, Spain

  • Hospital Son Espases

    RECRUITING

    Palma de Mallorca, Balearic Islands, 07120, Spain

  • Hospital Universitari i Politècnic La Fe

    NOT_YET_RECRUITING

    Valencia, València, 46009, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, Madrid, 28046, Spain

  • Hospital Universitario Marqués de Valdecilla

    RECRUITING

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario de Cruces

    RECRUITING

    Barakaldo, Bizcaia, 48903, Spain

  • Hospital Universitario de Donostia

    RECRUITING

    Donostia / San Sebastian, Guipuzcoa, 20014, Spain

  • Hospital Virgen de Arrixaca

    RECRUITING

    El Palmar, Murcia, 30120, Spain

  • Hospital Virgen de la Macarena

    RECRUITING

    Seville, Andalusia, 41009, Spain

  • Hospital Virgen del Rocío

    RECRUITING

    Seville, Andalusia, 41013, Spain

  • Hospital del Mar

    RECRUITING

    Barcelona, Barcelona, 08003, Spain

  • Hospital universitario de Canarias

    RECRUITING

    San Cristóbal de La Laguna, Santa Cruz de Tenerife, 38320, Spain

  • Parc Taulí Hospital Universitari

    RECRUITING

    Sabadell, Barcelona, 08208, Spain

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