Pill power: oral antibiotics may match IVs for serious heart infection
NCT ID NCT05398679
First seen Feb 28, 2026 · Last updated Jun 22, 2026 · Updated 16 times
Summary
This study compares oral antibiotics to intravenous (IV) antibiotics for treating infective endocarditis, a serious heart infection. Researchers want to see if taking pills at home works as well as getting IV treatment in a clinic. The trial involves 360 adults with specific types of infections and measures unplanned hospitalizations, deaths, relapses, and need for heart surgery.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hospital Bellvitge
RECRUITINGBarcelona, Barcelona, 08907, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Clinic i Provincial de Barcelona
RECRUITINGBarcelona, Barcelona, 08036, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital General Universitario Gregorio Marañón
RECRUITINGMadrid, Madrid, 28007, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital General de Alicante
RECRUITINGAlicante, Alicante, 03010, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Mútua de Terrassa
RECRUITINGTerrassa, Barcelona, 08221, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Ramón y Cajal
RECRUITINGMadrid, Madrid, 28034, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital San Pedro
RECRUITINGLogroño, La Rioja, 26006, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Sant Pau
RECRUITINGBarcelona, Barcelona, 08041, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Son Espases
RECRUITINGPalma de Mallorca, Balearic Islands, 07120, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitari i Politècnic La Fe
NOT_YET_RECRUITINGValencia, València, 46009, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario La Paz
RECRUITINGMadrid, Madrid, 28046, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Marqués de Valdecilla
RECRUITINGSantander, Cantabria, 39008, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario de Cruces
RECRUITINGBarakaldo, Bizcaia, 48903, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario de Donostia
RECRUITINGDonostia / San Sebastian, Guipuzcoa, 20014, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Virgen de Arrixaca
RECRUITINGEl Palmar, Murcia, 30120, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Virgen de la Macarena
RECRUITINGSeville, Andalusia, 41009, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Virgen del Rocío
RECRUITINGSeville, Andalusia, 41013, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital del Mar
RECRUITINGBarcelona, Barcelona, 08003, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital universitario de Canarias
RECRUITINGSan Cristóbal de La Laguna, Santa Cruz de Tenerife, 38320, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Parc Taulí Hospital Universitari
RECRUITINGSabadell, Barcelona, 08208, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
antibiotics (oral and intravenous)
What this could lead to
If successful, this could allow many patients with infective endocarditis to switch from IV to oral antibiotics earlier, reducing hospital stays and improving quality of life.
What could go wrong
This is a non-inferiority trial, so it aims to show oral treatment is not worse than IV, not necessarily better. Results may not apply to all types of infections or patients, and there is a risk of relapse or complications.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.