One or two infusions could replace weeks of antibiotics for heart infection
NCT ID NCT07699211
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study compares a long-acting antibiotic called dalbavancin to standard therapy for treating infective endocarditis, a serious infection of the heart valves caused by certain bacteria. Dalbavancin is given as one or two intravenous infusions, while standard therapy requires daily antibiotics for weeks. The trial includes 184 adults with left-sided heart valve infections and measures outcomes like survival, complications, and hospital stay length.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Dalbavancin
- What this could lead to
- If successful, this could offer a simpler treatment option for endocarditis, potentially reducing hospital stays with just one or two infusions instead of weeks of daily antibiotics.
- What could go wrong
- This is a phase 3 trial, but results may not apply to all patients, especially those with unstable conditions. Dalbavancin may not be as effective as standard therapy for all types of heart valve infections.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Deutsches Herzzentrum der Charité (DHZC)
Berlin, State of Berlin, 13353, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Helios Klinikum Erfurt GmbH
Erfurt, Thuringia, 99089, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinikum St. Gerog gGmbh
Leipzig, Saxony, 04129, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital Jena
Jena, Thuringia, 07747, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Freiburg
Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Hamburg-Eppendorf
Hamburg, Free and Hanseatic City of Hamburg, 20246, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Köln
Cologne, North Rhine-Westphalia, 50937, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Regensburg
Regensburg, Bavaria, 93053, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vivantes Auguste-Viktoria-Klinikum
Berlin, State of Berlin, 12157, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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