Infective endocarditis
MONDO:0000565Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called 'endocarditis,' although it is important to distinguish it from non-infective endocarditis. IE is caused bybacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damagethe heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue.
Also known as: endocarditis infective, endocarditis, infective
49 clinical trials for this condition and its sub-types.
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New study combines addiction treatment and IV antibiotics outside the hospital
Disease control CompletedThis study tested whether people with opioid use disorder and severe injection-related infections can be safely treated at home with antibiotics and buprenorphine (a medication for opioid use disorder). 71 participants were enrolled. The goal was to see if this integrated approac…
Phase: PHASE2 • Sponsor: Laura Fanucchi • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Pill power: could oral antibiotics replace IV drips for endocarditis?
Disease control CompletedThis study tested whether stable patients with a serious heart valve infection (endocarditis) could safely switch from intravenous (IV) antibiotics to oral amoxicillin pills. Over 300 adults participated. The goal was to see if the oral switch worked as well as continuing IV trea…
Phase: PHASE3 • Sponsor: University Hospital, Tours • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Pill power: could oral antibiotics replace IVs for serious heart infections?
Disease control CompletedThis study tested whether patients with a serious heart valve infection (endocarditis) caused by staph bacteria could safely switch from intravenous (IV) antibiotics to oral pills after at least 10 days of IV treatment. The trial involved 162 adults with left-sided endocarditis. …
Phase: PHASE3 • Sponsor: University Hospital, Tours • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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New device aims to filter out dangerous inflammation during heart surgery
Disease control CompletedThis study tested a device called HA-380® that filters inflammatory substances from the blood during heart-lung bypass in complex cardiac surgeries. Forty-one adults undergoing high-risk procedures like heart transplants or aortic dissection repairs were enrolled. The goal was to…
Phase: NA • Sponsor: Centre Hospitalier Universitaire Vaudois • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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New scan may spot hidden heart infections
Diagnosis CompletedThis study tested whether a special PET-CT scan using a radioactive tracer (18F-FDG) can improve diagnosis of infectious endocarditis on natural heart valves. Researchers scanned 31 adults with suspected endocarditis within 5 days of starting care. The goal was to see how well th…
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Diagnosis
Last updated Jun 27, 2026 13:01 UTC
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Brain scans may change how doctors treat heart infections
Knowledge-focused CompletedThis study looked at whether adding a brain MRI and a check by a nerve specialist could help doctors make better treatment decisions for people with a serious heart infection called infectious endocarditis. The infection can cause silent strokes, and the goal was to see if findin…
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Heart infection surgery outcomes examined in new study
Knowledge-focused CompletedThis study looked back at the medical records of 140 adults who had surgery for a serious heart infection called infective endocarditis. The goal was to see how many patients survived 30 days after surgery and what factors might lead to complications. Researchers also checked if …
Sponsor: Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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New imaging study aims to reduce misdiagnosis of heart valve infections
Knowledge-focused CompletedThis study involved 30 patients who had a transcatheter aortic valve replacement (TAVR). Researchers used a special PET/CT scan with a radioactive tracer to see how noninfected valves appear on imaging. The goal is to create a baseline pattern so doctors can better tell if a valv…
Sponsor: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Heart Infection's hidden brain damage tracked over time
Knowledge-focused CompletedThis study followed 100 patients who had infectious endocarditis, a serious heart infection, to see how brain lesions found on MRI scans change over time. Researchers compared initial MRI results with follow-up scans and tested thinking and memory skills. The goal was to understa…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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New study sheds light on anemia in endocarditis patients
Knowledge-focused CompletedThis completed study looked at 209 patients with bacterial endocarditis, a serious heart valve infection, to understand how common anemia is and what causes it. Researchers measured blood markers for inflammation and anemia from diagnosis up to 6 months after hospital discharge. …
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC