Infective endocarditis
MONDO:0000565Infective endocarditis (IE) is an infection of the inner lining of the heart chambers (endocardium) and valves. This condition is sometimes called 'endocarditis,' although it is important to distinguish it from non-infective endocarditis. IE is caused bybacteria, fungi, or other germs invading the bloodstream and attaching to the heart. IE can damagethe heart and cause serious and sometimes fatal complications. It can develop quickly or slowly depending on what type of germ is causing it and whether there is an underlying heart problem. Common symptoms of IE are fever and other flu-like symptoms, but signs and symptoms can vary. It can also cause problems in many other parts of the body besides the heart. IE is typically treated with antibiotics for several weeks; some individuals may need heart surgery to repair or replace heart valves or remove infected heart tissue.
Also known as: endocarditis infective, endocarditis, infective
49 clinical trials for this condition and its sub-types.
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Shorter antibiotic course after heart surgery for IV drug users shows promise
Disease control TerminatedThis study looked at whether people who had heart surgery for endocarditis (a serious heart infection) related to IV drug use could safely switch from IV antibiotics to oral pills after just two weeks. The goal was to see if this shorter hospital stay was safe and effective. The …
Phase: PHASE4 • Sponsor: West Virginia University • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Exercise and diet boost mental health in heart infection patients
Symptom relief TerminatedThis study tested whether adding physical rehabilitation and personalized nutrition to standard care helps patients with infective endocarditis (a serious heart infection) feel better during their hospital stay. The goal was to improve mental health and quality of life. The study…
Phase: NA • Sponsor: Johannes Grand • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC