New combo therapy aims to beat staph blood infections

NCT ID NCT04886284

Recruiting now Disease control Sponsor: Todd C. Lee MD MPH FIDSA Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether adding the antibiotic ertapenem to standard cefazolin treatment improves outcomes for adults with methicillin-susceptible Staphylococcus aureus bloodstream infections. About 60 participants will receive either the combination or a placebo. The study measures clinical success, including fever resolution and blood culture clearance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ertapenem (Invanz) added to cefazolin
What this could lead to: If it works, this could offer a more effective treatment for serious Staph bloodstream infections, potentially reducing complications and hospital stays.
What could go wrong: This is a small, early-phase trial with only 60 participants, so results may not apply broadly. Adding an antibiotic also raises risks of side effects and antibiotic resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bacterial endocarditis bacterial infectious disease with sepsis methicillin-susceptible staphylococcus aureus infectious disease staphylococcal infection staphylococcus aureus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STAPHYLOCOCCAL SEPSIS STAPHYLOCOCCUS AUREUS BACTEREMIA STAPHYLOCOCCUS AUREUS ENDOCARDITIS STAPHYLOCOCCUS AUREUS SEPTICEMIA

Contacts and locations

Locations

Foothills Medical Centre
RECRUITING

Calgary, Alberta, T2N4Z6, Canada
Hamilton Health Sciences (Hamilton General Hospital and Juravinski Hospital)
RECRUITING

Hamilton, Ontario, L8P1A2, Canada
Hospital de la Cité de la Sante
RECRUITING

Laval, Quebec, Canada
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)
RECRUITING

Montreal, Quebec, H4A3J1, Canada
Niagara Health - St. Catharines site
RECRUITING

Saint Catharines, Ontario, L2E6X2, Canada

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