New combo therapy aims to beat staph blood infections
NCT ID NCT04886284
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether adding the antibiotic ertapenem to standard cefazolin treatment improves outcomes for adults with methicillin-susceptible Staphylococcus aureus bloodstream infections. About 60 participants will receive either the combination or a placebo. The study measures clinical success, including fever resolution and blood culture clearance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ertapenem (Invanz) added to cefazolin
What this could lead to
If it works, this could offer a more effective treatment for serious Staph bloodstream infections, potentially reducing complications and hospital stays.
What could go wrong
This is a small, early-phase trial with only 60 participants, so results may not apply broadly. Adding an antibiotic also raises risks of side effects and antibiotic resistance.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Foothills Medical Centre
RECRUITINGCalgary, Alberta, T2N4Z6, Canada
Contact
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Hamilton Health Sciences (Hamilton General Hospital and Juravinski Hospital)
RECRUITINGHamilton, Ontario, L8P1A2, Canada
Contact
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Hospital de la Cité de la Sante
RECRUITINGLaval, Quebec, Canada
Contact Email: •••••@•••••
Contact
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Jewish General Hospital
RECRUITINGMontreal, Quebec, H3T 1E2, Canada
Contact
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McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)
RECRUITINGMontreal, Quebec, H4A3J1, Canada
Contact
Contact
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Niagara Health - St. Catharines site
RECRUITINGSaint Catharines, Ontario, L2E6X2, Canada
Contact