Double trouble for staph: could two antibiotics beat one?

NCT ID NCT07376889

Not yet recruiting Disease control Sponsor: Intermountain Health Care, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether using a combination of antibiotics is more effective than a single antibiotic for treating serious staph infections in the blood. About 2,096 adults with either methicillin-sensitive or methicillin-resistant staph will be randomly assigned to one group or the other. The main goal is to see which approach leads to better overall outcomes, including fewer complications and deaths within 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: combination of antibiotics (beta-lactam plus vancomycin or daptomycin)
What this could lead to: If it works, this could show that using two antibiotics together is more effective than one for treating serious staph bloodstream infections, potentially reducing complications and deaths.
What could go wrong: This is a large phase 4 trial, but results may not apply to all patients. Combination therapy could increase side effects or antibiotic resistance without improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

staphylococcus aureus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STAPHYLOCOCCUS AUREUS BACTEREMIA

Contacts and locations

Locations

Good Samaritan Hospital

Lafayette, Colorado, 80026, United States
Holy Rosary Hospital

Miles City, Montana, 59301, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
LDS Hospital

Salt Lake City, Utah, 84143, United States
Lutheran Medical Center

Wheat Ridge, Colorado, 80401, United States
McKay-Dee Hospital

Ogden, Utah, 84403, United States
Platte Valley Hospital

Brighton, Colorado, 80601, United States
Saint Joseph Hospital

Denver, Colorado, 80218, United States
St. George Regional Hospital

St. George, Utah, 84790, United States
St. James Hospital

Butte, Montana, 59701, United States
St. Mary's Regional Hospital

Grand Junction, Colorado, 81501, United States
St. Vincent Regional Hospital

Billings, Montana, 59101, United States
Utah Valley Hospital

Provo, Utah, 84604, United States

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