Double trouble for staph: could two antibiotics beat one?
NCT ID NCT07376889
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether using a combination of antibiotics is more effective than a single antibiotic for treating serious staph infections in the blood. About 2,096 adults with either methicillin-sensitive or methicillin-resistant staph will be randomly assigned to one group or the other. The main goal is to see which approach leads to better overall outcomes, including fewer complications and deaths within 30 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
combination of antibiotics (beta-lactam plus vancomycin or daptomycin)
What this could lead to
If it works, this could show that using two antibiotics together is more effective than one for treating serious staph bloodstream infections, potentially reducing complications and deaths.
What could go wrong
This is a large phase 4 trial, but results may not apply to all patients. Combination therapy could increase side effects or antibiotic resistance without improving outcomes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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Good Samaritan Hospital
Lafayette, Colorado, 80026, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Holy Rosary Hospital
Miles City, Montana, 59301, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Intermountain Medical Center
Murray, Utah, 84107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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LDS Hospital
Salt Lake City, Utah, 84143, United States
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Lutheran Medical Center
Wheat Ridge, Colorado, 80401, United States
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McKay-Dee Hospital
Ogden, Utah, 84403, United States
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Platte Valley Hospital
Brighton, Colorado, 80601, United States
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Saint Joseph Hospital
Denver, Colorado, 80218, United States
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St. George Regional Hospital
St. George, Utah, 84790, United States
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St. James Hospital
Butte, Montana, 59701, United States
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St. Mary's Regional Hospital
Grand Junction, Colorado, 81501, United States
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St. Vincent Regional Hospital
Billings, Montana, 59101, United States
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Utah Valley Hospital
Provo, Utah, 84604, United States
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