Which antibiotic wins against MRSA in the blood? new trial aims to find out

NCT ID NCT06637332

Recruiting now Disease control Sponsor: Todd C. Lee MD MPH FIDSA Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study compares two common antibiotics, daptomycin and vancomycin, to see which one works better for adults with MRSA bloodstream infections. About 300 participants will be randomly assigned to one of the two drugs. The goal is to find which treatment leads to fewer complications and better survival.

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Conditions

The condition(s) this trial relates to.

bacterial endocarditis methicillin-resistant staphylococcus aureus infectious disease staphylococcus aureus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

S. AUREUS BACTEREMIA S. AUREUS BLOODSTREAM INFECTION STAPHYLOCOCCUS AUREUS BACTEREMIA STAPHYLOCOCCUS AUREUS ENDOCARDITIS STAPHYLOCOCCUS AUREUS SEPTICEMIA

Contacts and locations

Locations

Blacktown Hospital
RECRUITING

Blacktown, New South Wales, NSW 2148, Australia
Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
Concord Repatriation and General Hospital
RECRUITING

Concord, New South Wales, 2139, Australia
Fiona Stanley Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Fraser Health Authority (Surrey Memorial Hospital)
RECRUITING

Surrey, British Columbia, V3V1Z2, Canada
Hamilton Health Sciences (Hamilton General Hospital and Juravinski Hospital)
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T 1E2, Canada
John Hunter Hospital
RECRUITING

Newcastle, New South Wales, 2305, Australia
McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)
RECRUITING

Montreal, Quebec, H4A3S1, Canada
Monash Health - Casey Hospital
RECRUITING

Berwick, Victoria, 3806, Australia
Monash Medical Campus (Monash Medical Centre + Jesse McPherson Private Hospital)
RECRUITING

Clayton, Victoria, 3168, Australia
Newfoundland Health Services (Health Sciences Centre and St. Clare's Mercy Hospital)
RECRUITING

St. John's, Newfoundland and Labrador, Canada
Royal Brisbane and Women's Hospital
RECRUITING

Herston, Queensland, 4029, Australia
Royal Melbourne Hospital
RECRUITING

Parkville, Victoria, 3050, Australia
Royal Perth Hospital
RECRUITING

Perth, Western Australia, 6000, Australia
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
University of Alberta Hospital
RECRUITING

Edmonton, Alberta, Canada
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia

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