Could less be more? major trial questions routine antibiotic for heart valve infections

NCT ID NCT07253688

Recruiting now Disease control Sponsor: Todd C. Lee MD MPH FIDSA Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 330 adults with a serious heart valve infection (prosthetic valve endocarditis) caused by S. aureus bacteria. It compares the standard approach of giving the antibiotic rifampin against not giving it, to see if skipping it is just as safe and effective. The goal is to reduce unnecessary side effects while still controlling the infection.

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Conditions

The condition(s) this trial relates to.

bacterial endocarditis infective endocarditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTHETIC VALVE ENDOCARDITIS STAPHYLOCOCCUS AUREUS ENDOCARDITIS

Contacts and locations

Locations

McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)
RECRUITING

Montreal, Quebec, H4A4S1, Canada

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