One dose before surgery: could an antifungal cut serious Post-Op risks?

NCT ID NCT06770530

Recruiting now Disease control Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests whether giving a single dose of the antifungal drug fluconazole just before bladder removal surgery (cystectomy) can lower the risk of serious postoperative complications. The study includes 420 adults scheduled for cystectomy with an ileal conduit, who will receive either fluconazole or a placebo (saline) intravenously. Researchers will track complications like infections and bowel issues, as well as how long patients stay in the hospital. The goal is to see if this simple preventive step can improve recovery after a major operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fluconazole (an antifungal drug) given as a single intravenous dose before surgery, compared with a placebo (saline solution).
What this could lead to: If effective, a single dose of fluconazole could become a standard preventive measure to reduce serious complications after bladder removal surgery, improving recovery and shortening hospital stays.
What could go wrong: This is a single trial, and the benefit is not guaranteed. Fluconazole may not reduce complications, and there are risks of allergic reactions or interactions with other medications.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTECTOMY

Contacts and locations

Locations

Department of Urology, Rigshospitalet
RECRUITING

Copenhagen, 2100, Denmark

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