Double antibiotic attack: could a combo therapy beat strep in the blood?

NCT ID NCT07240077

Not yet recruiting Disease control Sponsor: Mahidol University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares standard beta-lactam antibiotics alone versus beta-lactam plus levofloxacin in adults with streptococcal bacteremia (bacteria in the blood). 165 participants will be randomly assigned to receive either the combination or monotherapy. The goal is to see if adding levofloxacin reduces complications like persistent infection, death, or spread of infection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: levofloxacin (antibiotic) added to beta-lactam antibiotics
What this could lead to: If adding levofloxacin works, it could become a new standard treatment for streptococcal bloodstream infections, reducing complications and deaths.
What could go wrong: This is a relatively small, early-stage trial (165 participants) and may not show a clear benefit. Adding levofloxacin also carries risks like antibiotic resistance and side effects.

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Conditions

The condition(s) this trial relates to.

bacterial infectious disease with sepsis streptococcal infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BACTEREMIA STREPTOCOCCUS INFECTION

Contacts and locations

Locations

Faculty of Medicine Siriraj Hospital

Bangkok, Thailand
Maharaj Nakhon Ratchasima

Nakhon Ratchasima, Thailand
Maharaj Nakorn Chiang Mai Hospital

Chiang Mai, Thailand
Ratchburi Hospital

Ratchaburi, Thailand

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