Can a new antibiotic combo beat Drug-Resistant urinary infections in the blood?
NCT ID NCT07725848
First seen Jul 24, 2026 · Last updated Jul 24, 2026
Summary
This study is testing whether a new antibiotic combination, cefepime/enmetazobactam, works as well as the best current treatments for complicated urinary tract infections that have spread to the bloodstream. These infections are caused by bacteria resistant to many common antibiotics. Researchers will compare how quickly the infection clears from the blood in patients receiving the new combination versus standard therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a new antibiotic combination called cefepime/enmetazobactam (FEP/META)
- What this could lead to
- If effective, this antibiotic combination could offer a new treatment option for hard-to-treat urinary tract infections that have spread to the blood, especially those resistant to multiple drugs.
- What could go wrong
- This is an observational study, not a randomized trial, so results may be less definitive. The antibiotic may not prove superior to existing treatments, and resistance could still develop.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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ASST Fatebenefratelli Sacco
Milan, Italy, 20157, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Garibaldi
Catania, Italy, 95122, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy, 40138, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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