Bacterial infectious disease with sepsis

This study follows women who previously received the GBS-NN/NN2 vaccine during pregnancy to see how long their immune protection lasts. It also tests whether a booster dose given in a new pregnancy is safe and boosts immunity, aiming to protect newborns from group B strep infecti…

This study planned to test a treatment called MET-2, a mix of gut bacteria, to help clear antibiotic-resistant germs from the body after a bloodstream infection. It was designed for adults not in intensive care who had a resistant infection. The trial was withdrawn before enrolli…

This study tests whether 7 days of antibiotics works as well as the standard 14 days for treating a serious bloodstream infection caused by Pseudomonas bacteria. About 300 adults who have already received 6 days of treatment will be randomly assigned to stop at 7 days or continue…

This study tests whether giving the steroid hydrocortisone early, right when shock is diagnosed, helps very small preterm babies (under 1500 grams) recover faster. Researchers will compare babies who get standard shock treatment plus hydrocortisone to those who get standard treat…

This study looks at whether taking blood for culture in one go is as good as taking it from two separate spots to find bloodstream infections. Adults with suspected infections will have blood drawn twice: first, a larger sample from one vein, then a smaller sample from another ve…

This study tests a finger-clasp device called Lab Clasp that measures lactate from fluid just under the skin, similar to a pulse oximeter. Researchers want to see if it matches standard blood tests in 6 healthy adults. If it works, it could make sepsis monitoring easier and less …

This study is testing whether a blood test called Monocyte Distribution Width (MDW) can quickly identify patients with bacteria in their blood (bacteremia) in the emergency department. Researchers will observe 50,000 patients who have blood cultures ordered, comparing MDW results…

This study looks back at medical records from four hospitals in Thailand to understand what happens when doctors reduce antibiotic treatment (de-escalation) in patients who received short-course IV antibiotics. It compares outcomes like new resistant infections and death between …

This study at St. Jude Children's Research Hospital is testing whether a next-generation DNA test can predict bloodstream infections in children and teens with cancer who are at high risk. Current methods often detect infections too late, leading to severe illness or death. The g…

This study looks at how the immune system bounces back in people who survive a severe bloodstream infection caused by Staphylococcus aureus bacteria. Researchers are measuring specific immune markers, like HLA-DR on monocytes, to see if recovery differs between people with and wi…

This study looks at small molecules called microRNAs in the blood of people with sepsis, a severe bloodstream infection. Researchers want to see if changes in these molecules can help predict who will survive. About 150 participants will provide blood samples, and their microRNA …

This study planned to use a biomarker test called NGAL to predict which critically ill children and newborns would develop severe kidney injury. The goal was to help doctors make better decisions about fluids and dialysis. However, the study was withdrawn before enrolling any par…

This study tests a new microfluidic device that uses a very small blood sample to measure how well immune cells (neutrophils) function in premature newborns. The goal is to see if this test can predict which babies will develop sepsis, a life-threatening infection. Researchers wi…

This study tests whether using rapid, advanced lab tests to identify the exact bacteria causing a severe infection can help doctors choose the right antibiotics faster. About 190 adults with sepsis in Greek ICUs will either get standard care or the new testing strategy. The goal …

This study looks at how the antibiotic cefazolin behaves in the blood of people on chronic hemodialysis who have catheter infections. Researchers will take blood samples at different times to measure drug levels. The goal is to find the best dose to treat infections while avoidin…

This study looks at bacteria that enter the bloodstream during dental treatment for gum disease. Researchers want to find biological markers that can quickly tell if someone has a bloodstream infection, which could help diagnose sepsis faster. About 100 adults with gum disease ar…

This study looks back at medical records of about 5,000 people with a serious bloodstream infection caused by a common bacterium. Researchers compare two antibiotic treatments to see which one leads to better survival and fewer side effects. The goal is to find out if a newer opt…