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New test combo could slash unnecessary antibiotic use in sepsis

NCT ID NCT05909683

Ongoing Knowledge-focused Sponsor: Hellenic Institute for the Study of Sepsis Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using rapid, advanced lab tests to identify the exact bacteria causing a severe infection can help doctors choose the right antibiotics faster. About 190 adults with sepsis in Greek ICUs will either get standard care or the new testing strategy. The goal is to reduce the number of days patients need strong, broad-spectrum antibiotics.

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Conditions

The condition(s) this trial relates to.

acute pyelonephritis bacterial infectious disease with sepsis Infections infectious disease with sepsis nosocomial infection pneumonia Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPSIS

Contacts and locations

Locations

  • 1st Department of Internal Medicine - General Hospital of Athens Sismanoglio- Amalia Fleming

    Athens, 15126, Greece

  • 1st Department of Internal Medicine, General Hospital of Athens KORGIALENIO-BENAKIO E.E.S.

    Athens, 11526, Greece

  • 1st Department of Internal Medicine, General Hospital of Elefsina "Thriasio"

    Athens, Elefsina, 19600, Greece

  • 1st Department of Internal Medicine- General Hospital of Athens GENNIMATAS

    Athens, 11527, Greece

  • 1st University Department of Internal Medicine, AHEPA University General Hospital of Thessaloniki

    Thessaloniki, 54636, Greece

  • 2nd Department of Internal Medicine, General Hospital of Piraeus "Tzaneio"

    Piraeus, 18536, Greece

  • 2nd Department of Internal Medicine, University General Hospital of Alexandroupolis

    Alexandroupoli, Greece

  • 2nd Propaedeutic Department of Internal Medicine, Attikon University Hospital

    Athens, Chaidari, 12462, Greece

  • 3rd Department of Internal Medicine - General State Hospital of Nikaia "Saint Panteleimon" - West Attica General Hospital "Agia Varvara"

    Athens, 18454, Greece

  • 3rd University Department of Internal Medicine, Sotiria Athens General Hospital

    Athens, 11527, Greece

  • 4th Department of Internal Medicine, Attikon University Hospital

    Athens, Chaidari, 12462, Greece

  • Clinic of Intensive Care and Pulmonary Diseases, Aghioi Anargyroi Kifissia General Oncologic Hospital

    Kifissia, 14564, Greece

  • Intensive Care Unit of Center for Respiratory Failure, Sotiria Chest Diseases Athens General Hospital

    Athens, Attica, 11527, Greece

  • Intensive Care Unit, Ippokrateion General Hospital

    Thessaloniki, 54642, Greece

  • New Multivalent Intensive Care Unit, Sotiria Chest Diseases Athens General Hospital

    Athens, Attica, 11527, Greece

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