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New study aims to cut unnecessary antibiotics in newborns

NCT ID NCT06845332

Recruiting now Knowledge-focused Sponsor: Franciscus Gasthuis Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study will roll out three proven antibiotic stewardship strategies in Dutch hospitals to see if they reduce unnecessary antibiotic use in newborns with suspected early-onset sepsis. Researchers will compare data from before and after the strategies are put in place, involving up to 55,000 babies born at 34 weeks or later. The goal is to make care more consistent and safer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

antibiotic stewardship strategies (EOS calculator, procalcitonin-guided therapy, IV-to-oral switch)

What this could lead to

If successful, this could help standardize safe antibiotic use in newborns, reducing unnecessary treatment and hospital stays.

What could go wrong

This is an implementation study, not a test of new drugs. Results may vary across hospitals, and the strategies may not reduce antibiotic use as expected.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

neonatal sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY ONSET SEPSIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-••••

Locations

  • Admiraal de Ruyter Ziekenhuis

    RECRUITING

    Goes, Netherlands

  • Albert Schweitzer Ziekenhuis

    RECRUITING

    Dordrecht, Netherlands

  • Antonius Ziekenhuis Sneek

    RECRUITING

    Sneek, Netherlands

  • Canisius Wilhelmina Ziekenhuis

    RECRUITING

    Nijmegen, Netherlands

  • Catharina Ziekenhuis

    RECRUITING

    Eindhoven, Netherlands

  • Gelre Ziekenhuis

    RECRUITING

    Apeldoorn, Netherlands

  • Medisch Centrum Leeuwarden

    RECRUITING

    Leeuwarden, Netherlands

  • Noordwest Ziekenhuisgroep

    RECRUITING

    Alkmaar, Netherlands

  • Tjongerschans Ziekenhuis

    RECRUITING

    Heerenveen, Netherlands

  • Treant Ziekenhuis

    RECRUITING

    Emmen, Netherlands

  • Zuyderland Medisch

    RECRUITING

    Heerlen, Netherlands

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