New study aims to cut unnecessary antibiotics in newborns
NCT ID NCT06845332
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study will roll out three proven antibiotic stewardship strategies in Dutch hospitals to see if they reduce unnecessary antibiotic use in newborns with suspected early-onset sepsis. Researchers will compare data from before and after the strategies are put in place, involving up to 55,000 babies born at 34 weeks or later. The goal is to make care more consistent and safer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- antibiotic stewardship strategies (EOS calculator, procalcitonin-guided therapy, IV-to-oral switch)
- What this could lead to
- If successful, this could help standardize safe antibiotic use in newborns, reducing unnecessary treatment and hospital stays.
- What could go wrong
- This is an implementation study, not a test of new drugs. Results may vary across hospitals, and the strategies may not reduce antibiotic use as expected.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Admiraal de Ruyter Ziekenhuis
RECRUITINGGoes, Netherlands
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Albert Schweitzer Ziekenhuis
RECRUITINGDordrecht, Netherlands
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Antonius Ziekenhuis Sneek
RECRUITINGSneek, Netherlands
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Canisius Wilhelmina Ziekenhuis
RECRUITINGNijmegen, Netherlands
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Catharina Ziekenhuis
RECRUITINGEindhoven, Netherlands
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Gelre Ziekenhuis
RECRUITINGApeldoorn, Netherlands
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Medisch Centrum Leeuwarden
RECRUITINGLeeuwarden, Netherlands
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Noordwest Ziekenhuisgroep
RECRUITINGAlkmaar, Netherlands
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Tjongerschans Ziekenhuis
RECRUITINGHeerenveen, Netherlands
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Treant Ziekenhuis
RECRUITINGEmmen, Netherlands
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Zuyderland Medisch
RECRUITINGHeerlen, Netherlands
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New study aims to perfect antibiotic dosing for newborns
- Could shorter antibiotics work just as well for newborns?
- NICU antibiotic study questions routine use for tiniest babies
- Blood test could spare thousands of preemies from unnecessary antibiotics