Pseudomonas infection

This study tested a single dose of a special virus mixture (bacteriophages) given through a vein to adults with cystic fibrosis who have a chronic lung infection with Pseudomonas bacteria. The goal was to see if the treatment is safe and can reduce the amount of bacteria in the l…

This study tested an inhaled drug called RSP-1502, which combines the antibiotic tobramycin with a substance called CaEDTA, in 71 people with cystic fibrosis who have chronic Pseudomonas lung infections. The goal was to check safety and find the right dose. Participants received …

This study looked at 200 adults with multidrug-resistant Pseudomonas infections who were treated with the antibiotic combination ceftolozane-tazobactam. Researchers tracked how many patients survived at 30 days and while in the hospital, and whether follow-up cultures showed the …

This study tested a single dose of CMTX-101, an antibody designed to break up bacterial biofilms, in 43 adults with cystic fibrosis who have chronic lung infections with Pseudomonas aeruginosa. The goal was to see if adding CMTX-101 to standard inhaled antibiotics is safe and tol…

This study tested whether cleaning therapy dogs with a special disinfectant (chlorhexidine) before hospital visits could reduce the spread of harmful germs to children. The trial involved 45 children aged 3 to 17 who interacted with therapy dogs. Researchers checked if the cleani…

This study tested whether an inhaled antibiotic (tobramycin), taken alone or with an oral antibiotic (ciprofloxacin), can permanently clear Pseudomonas aeruginosa infections from the lungs of people with bronchiectasis. The trial involved 371 adults and compared these treatments …

This study tested an inhaled mixture of bacteria-killing viruses (phages) in 48 adults with bronchiectasis and chronic Pseudomonas lung infections. Participants received either the phage therapy or a placebo by inhalation. The goal was to see if the phages could safely reduce the…

This study tested two new types of biosensor platforms to detect viruses, bacteria, and parasites in blood and respiratory samples. The goal was to see if these devices could be accurate, fast, and cheap alternatives to standard lab tests. Researchers enrolled 149 adults with or …

This study looked at 197 ICU patients with bloodstream infections caused by carbapenem-resistant bacteria (superbugs). Researchers used machine learning to analyze patient data and predict which patients were at higher risk of dying. The goal is to create a tool that helps doctor…

This study aimed to create a smart surveillance strategy for carbapenem-resistant Pseudomonas aeruginosa (CRPA), a superbug that causes hard-to-treat infections in hospitals. Researchers collected samples from over 2,100 healthy people, patients, and hospital environments in the …

This study looked at blood neutrophils (a type of immune cell) in 47 adults with cystic fibrosis. Researchers compared these cells between patients and healthy donors, and also examined how chronic infection, CFTR modulator drugs, and lung flare-ups affect neutrophil behavior. Th…