Virus-Eating therapy inhaled to fight stubborn lung bug

NCT ID NCT05616221

First seen Jan 07, 2026 · Last updated May 15, 2026 · Updated 16 times

Summary

This study tested an inhaled treatment called AP-PA02, which uses special viruses (phages) to attack Pseudomonas bacteria in the lungs. It involved 48 adults with bronchiectasis (a lung condition) and a long-term Pseudomonas infection. The goal was to see if the treatment is safe and can reduce the amount of bacteria in sputum.

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Contacts and locations

Locations

  • Georgetown University Hospital / Pulmonary Critical Care and Sleep Medicine

    Washington D.C., District of Columbia, 20007, United States

  • Johns Hopkins University School of Medicine

    Baltimore, Maryland, 21224, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Mayo Clinic/Pulmonary, Critical Care, and Sleep Medicine

    Jacksonville, Florida, 32224, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • New York Medical College

    Hawthorne, New York, 10595, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Rutgers Robert Wood Johnson Medical School

    New Brunswick, New Jersey, 08901, United States

  • Southern California Institute for Respiratory Diseases Cedars-Sinai West Tower

    Los Angeles, California, 90048, United States

  • Southwest General Healthcare Center

    Fort Myers, Florida, 33907, United States

  • St. Lukes Hospital

    Boise, Idaho, 83702, United States

  • TecTum Medical Research, Inc.

    Hollywood, Florida, 33024, United States

  • The University of Kansas Medical Center / Dept of Medicine

    Kansas City, Kansas, 66160, United States

  • UCONN Health

    Farmington, Connecticut, 06030, United States

  • University Hospitals of Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Cincinnati - College of Medicine

    Cincinnati, Ohio, 45267, United States

  • University of Miami

    Miami, Florida, 33146, United States

  • University of Pennslyvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Texas Health Science Center at Tyler

    Tyler, Texas, 75708, United States

  • University of Washington Medical Center

    Seattle, Washington, 98195, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37203, United States

  • Velocity Clinical Research

    Mobile, Alabama, 36608, United States

  • Virginia Commonwealth University (VCU)

    Richmond, Virginia, 23298, United States

Conditions

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