New antibody tackles stubborn biofilms in cystic fibrosis lungs

NCT ID NCT06159725

Completed Disease control Sponsor: Clarametyx Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a single dose of CMTX-101, an antibody designed to break up bacterial biofilms, in 43 adults with cystic fibrosis who have chronic lung infections with Pseudomonas aeruginosa. The goal was to see if adding CMTX-101 to standard inhaled antibiotics is safe and tolerable. The trial focused on safety and how the drug moves through the body, not yet on whether it improves lung function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

CMTX-101 (a monoclonal antibody that disrupts bacterial biofilms)

What this could lead to

If it works, this could point toward a new way to make antibiotics more effective against stubborn lung infections in cystic fibrosis.

What could go wrong

This was a small, early-phase safety study (43 people), so it's too soon to know if it actually helps. The treatment is added to existing antibiotics, not a standalone cure.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cystic fibrosis Persistent Infection Pseudomonas aeruginosa infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTIC FIBROSIS PERSISTENT INFECTION

Contacts and locations

Show contact details

Locations

Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Central Florida Pulmonary Group, PA

Orlando, Florida, 32803, United States
Cystic Fibrosis Institute

Northfield, Illinois, 60093, United States
Johns Hopkins University

Baltimore, Maryland, 21287, United States
Lenox Hill Hospital

New York, New York, 10075, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
National Jewish Health

Denver, Colorado, 80206, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
New York Medical College

Hawthorne, New York, 10532, United States
PennState Health

Hershey, Pennsylvania, 17003, United States
Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
St Luke's Sleep Medicine and Research Center

Boise, Idaho, 83702, United States
Stanford University

Palo Alto, California, 94304, United States
UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
University of Alabama, Birmingham

Birmingham, Alabama, 35294, United States
University of California, San Francisco

San Franciso, California, 94143, United States
University of Kansas

Kansas City, Kansas, 66160, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Utah

Salt Lake City, Utah, 84132, United States
Vanderbilt University

Nashville, Tennessee, 37235, United States
Virginia Commonwealth University

Richmond, Virginia, 23219, United States