New hope for lung infection: inhaled antibiotic aims to eradicate tough bacteria

NCT ID NCT06093191

Completed Disease control Sponsor: Jin-Fu Xu Source: ClinicalTrials.gov ↗

First seen Apr 18, 2026 · Last updated May 02, 2026 · Updated 3 times

Summary

This study tested whether an inhaled antibiotic (tobramycin) can clear Pseudomonas aeruginosa infections in people with bronchiectasis, a chronic lung condition. 371 adults with a first or new Pseudomonas infection received either inhaled tobramycin alone, tobramycin plus oral ciprofloxacin, or a placebo (saline). The goal was to see if the infection could be eliminated and stay gone for at least 12 weeks. The trial is complete and results will show if this approach works better than no treatment.

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Contacts and locations

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Locations

Affiliated Hospital of Guangdong Medical University

Zhanjiang, Guangdong, China
Affiliated Hospital of Jiaxing University

Jiaxing, Zhejiang, China
Affiliated Hospital of Nantong University

Nantong, Jiangsu, China
Anhui Chest Hospital

Hefei, Anhui, China
Baoshan Hospital, Shanghai University of Traditional Chinese Medicine

Shanghai, Shanghai Municipality, China
Beijing Chao-Yang Hospital, Capital Medical University

Beijing, Beijing Municipality, China
Fujian Provincial Hospital

Fuzhou, Fujian, China
Guizhou Provincial People's Hospital

Guiyang, Guizhou, China
Hainan Provincial People's Hospital

Haikou, Hainan, 570311, China
Henan Provincial People's Hospital

Zhengzhou, Henan, China
Huzhou Central Hospital Affiliated to Zhejiang University School of Medicine

Huzhou, Zhejiang, China
Medical Service Community of People's Hospital of Fenghua

Ningbo, Zhejiang, China
Ningbo Medical Center Lihuili Hospital

Ningbo, Zhejiang, China
Northern Jiangsu People's Hospital

Yangzhou, Jiangsu, China
Peking Union Medical College Hospital

Beijing, Beijing Municipality, China
Putuo People's Hospital, School of Medicine, Tongji University

Shanghai, Shanghai Municipality, China
Qilu Hospital, Shandong University

Jinan, Shangdong, China
Ruijin Hospital, Shanghai Jiaotong University

Shanghai, Shanghai Municipality, 200025, China
Shanghai Fifth People's Hospital, Fudan University

Shanghai, Shanghai Municipality, 200245, China
Shanghai General Hospital, Shanghai Jiaotong University

Shanghai, Shanghai Municipality, China
Shanghai Sixth People's Hospital, Shanghai Jiao Tong University

Shanghai, China
Shanxi Bethune Hospital

Taiyuan, Shanxi, 030032, China
Shengjing Hospital of China Medical University

Shenyang, Liaoning, China
Shenzhen Institute of Respiratory Diseases

Shenzhen, Guangdong, China
Songjiang Hospital, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, China
Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University

Suzhou, Jiangsu, China
The Affiliated Hospital of Hangzhou Normal University

Hangzhou, Zhejiang, China
The Eighth Affiliated Hospital of Sun Yat-Sen University

Shenzhen, Guangdong, China
The Eighth People's Hospital of Shanghai

Shanghai, Shanghai Municipality, China
The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, China
The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China
The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine

Guangzhou, Guangdong, China
The First Affiliated Hospital of Kunming Medical University

Kunming, Yunnan, 650032, China
The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China
The First Affiliated Hospital of Ningbo University

Ningbo, Zhejiang, China
The First Affiliated Hospital of Shandong First Medical University

Jinan, Shandong, China
The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China
The First Affliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China
The First Hospital of China Medical University

Shenyang, Liaoning, China
The First Hospital of Jilin University

Changchun, Jilin, China
The First People's Hospital of Anning Affiliated to Kunming University of Science and Technology

Anning, Yunnan, China
The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China
The Second Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, China
The Second Affiliated Hospital of Jiaxing University

Jiaxing, China
The Second Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China
The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, China
The Second Xiangya Hospital of Central South University

Changsha, Hunan, China
The Shangrao People's Hospital

Shangrao, Jiangxi, China
The Sixth People's Hospital of Nantong

Nantong, Jiangsu, China
The Third Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China
Tongji Hospital, School of Medicine, Tongji University; Shanghai Pulmonary Hospital, School of Medicine, Tongji University; Huadong Hospital, School of Medicine, Fudan University

Shanghai, Shanghai Municipality, 200065; 200433; 200040, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China
Tsingtao Municipal Hospital, Qingdao Hospital of University Health And Rehabilitation Sciences

Qingdao, Shandong, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China
West China Hospital, Sichuan University

Chengdu, Sichuan, China
Xiangya Hospital, Central South University

Changsha, Hunan, China
Yangpu Hospital, Tongji University

Shanghai, Shanghai Municipality, China
Zhengzhou People's Hospital

Zhengzhou, Henan, China
Zhongshan Hospital, Fudan University

Shanghai, Shanghai Municipality, China

Conditions

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BRONCHIECTASIS ADULT PSEUDOMONAS AERUGINOSA INFECTION