Could viruses be the new weapon against tough lung infections in cystic fibrosis?
NCT ID NCT05453578
First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times
Summary
This study tested a single dose of a special virus mixture (bacteriophages) given through a vein to adults with cystic fibrosis who have a chronic lung infection with Pseudomonas bacteria. The goal was to see if the treatment is safe and can reduce the amount of bacteria in the lungs. 72 participants were enrolled across multiple U.S. sites, and the study compared different doses against a placebo.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Baylor College of Medicine
Houston, Texas, 77030-3411, United States
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Case Western Reserve University
Cleveland, Ohio, 44106, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Emory University - Adult Cystic Fibrosis Program
Atlanta, Georgia, 30324, United States
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Johns Hopkins University
Baltimore, Maryland, 21205, United States
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Michigan Medicine
Ann Arbor, Michigan, 48109, United States
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Northwell Health
New Hyde Park, New York, 11050, United States
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Stanford University
Stanford, California, 94305, United States
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The University of Arizona - Banner University Medical Center Tucson Campus - Tucson
Tucson, Arizona, 85724-0001, United States
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University of California Davis Health
Sacramento, California, 95816, United States
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University of California Los Angeles Medical Center - Westwood Clinic
Los Angeles, California, 90095, United States
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University of California, San Diego
La Jolla, California, 92037, United States
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University of California, San Diego (UCSD) - Antiviral Research Center (AVRC)
La Jolla, California, 92121, United States
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University of Minnesota Medical Center
Minneapolis, Minnesota, 55455-0341, United States
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University of South Florida/Tampa General Hospital
Tampa, Florida, 22612, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Virginia
Charlottesville, Virginia, 22908, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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Yale North Haven Medical Center- Winchester Center for Lung Disease
North Haven, Connecticut, 06473, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A smartphone tool may help cystic fibrosis patients survive the lung transplant waitlist
- Can a smartphone app reveal how CF treatments really work at home?
- Can a peer coach help young people take control of their chronic illness?
- Could a single antibiotic be enough for cystic fibrosis lung infections?
- Early use of powerful CF drugs may boost growth in young children
- Hands-On therapy may soothe cystic fibrosis pain without drugs